Goto T, Kawahara M, Sakamoto N, Ohi Y, Nagata S, Yanase I, Hanabusa A, Imamura A, Shimada T, Kawabata T
Jpn J Antibiot. 1986 Apr;39(4):996-1006.
Antibacterial activities of imipenem (MK-0787), cefazolin (CEZ), cefmenoxime (CMX) and cefoperazone (CPZ) were measured by using an agar dilution method against 243 strains of bacteria isolated from the patients with urinary tract infections. The MIC80 of MK-0787 against S. epidermidis, E. faecalis, E. coli, K. pneumoniae, E. cloacae, S. marcescens, P. mirabilis, P. vulgaris and P. aeruginosa was less than or equal to 0.10, 3.13, less than or equal to 0.10, 0.20, 0.78, 1.56, 3.13, 3.13 and 6.25 micrograms/ml, respectively. MK-0787 was more active than CEZ, CMX and CPZ against all bacterial species except Proteus spp. Imipenem/cilastatin sodium (MK-0787/MK-0791) 500 mg/500 mg two times a day for 5 days was given to 31 cases of chronic complicated urinary tract infections and a case of acute prostatitis. Overall clinical effectiveness rate judged by the criteria proposed by the Japanese UTI committee in 22 cases of chronic complicated urinary tract infection treated with MK-0787/MK-0791 was evaluated to be 86% including excellent in 6 cases, moderate in 13 cases and poor in 3 cases. As side effects, 2 cases encountered eruption or anorexia. Abnormal laboratory findings were observed in 6 cases.
采用琼脂稀释法测定了亚胺培南（MK-0787）、头孢唑林（CEZ）、头孢甲肟（CMX）和头孢哌酮（CPZ）对243株从尿路感染患者中分离出的细菌的抗菌活性。MK-0787对表皮葡萄球菌、粪肠球菌、大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌、黏质沙雷菌、奇异变形杆菌、普通变形杆菌和铜绿假单胞菌的MIC80分别小于或等于0.10、3.13、小于或等于0.10、0.20、0.78、1.56、3.13、3.13和6.25微克/毫升。除变形杆菌属外，MK-0787对所有细菌种类的活性均高于CEZ、CMX和CPZ。给予31例慢性复杂性尿路感染患者和1例急性前列腺炎患者亚胺培南/西司他丁钠（MK-0787/MK-0791）500毫克/500毫克，每日2次，共5天。根据日本泌尿道感染委员会于1999年提出的标准，对22例接受MK-0787/MK-0791治疗的慢性复杂性尿路感染患者进行评估，总体临床有效率为86%，其中6例为优，13例为中，3例为差。作为副作用，2例出现皮疹或厌食。6例观察到实验室检查结果异常。
