Iwaki M, Sato H, Makinoda S, Demise M, Tabata M, Yamaguchi T, Takaoka H, Shinkai N, Okubo H, Sato H
Jpn J Antibiot. 1986 Jun;39(6):1509-13.
The MK-0787/MK-0791 is a combination of imipenem (a carbapenem antibiotic) and cilastatin sodium (a dehydro peptidase-I inhibitor) in a 1 to 1 ratio, which produces a higher urinary recovery of imipenem than imipenem alone. The MK-0787/MK-0791 was used in 8 female patients with intrapelvic infections. Clinical efficacies were very good in all the patients. There were neither subjective nor objective side effects nor abnormal laboratory findings.
MK-0787/MK-0791是亚胺培南(一种碳青霉烯类抗生素)和西司他丁钠(一种脱氢肽酶-I抑制剂)按1:1比例的组合,与单独使用亚胺培南相比,它能使亚胺培南在尿液中的回收率更高。MK-0787/MK-0791用于8例患有盆腔内感染的女性患者。所有患者的临床疗效都非常好。既没有主观也没有客观的副作用,实验室检查结果也无异常。