Arai T
Jpn J Antibiot. 1986 May;39(5):1237-40.
Incidences of methicillin-resistant strains of Staphylococcus (MRS) have been increasing because of the extensive uses of cephalosporins and semisynthetic beta-lactamase-resistant penicillins. Most of these strains are known to be resistant to beta-lactam antibiotics due to their production of penicillinases and mutated penicillin-binding proteins. Our recent clinical isolates of MRS were also suspected to be this type because of their temperature sensitive resistance to methicillin. We studied in vitro antibiotic activity of cefuzoname (CZON) a cephalosporin developed against Staphylococcus, against these MRS in comparison with those of the representative cephalosporins, cefazolin (CEZ), cefamandole (CMD), cefotiam (CTM), cefoperazone (CPZ) and cefpiramide (CPM). It was found that CZON was the most active against MRS among these cephalosporins under normal body temperatures as well as at lower temperatures.
由于头孢菌素和半合成耐β-内酰胺酶青霉素的广泛使用，耐甲氧西林葡萄球菌（MRS）的发生率一直在上升。已知这些菌株中的大多数由于产生青霉素酶和突变的青霉素结合蛋白而对β-内酰胺类抗生素耐药。我们最近的MRS临床分离株也因其对甲氧西林的温度敏感性耐药而被怀疑是这种类型。我们研究了针对葡萄球菌开发的头孢菌素头孢唑南（CZON）对这些MRS的体外抗菌活性，并与代表性头孢菌素头孢唑林（CEZ）、头孢孟多（CMD）、头孢替安（CTM）、头孢哌酮（CPZ）和头孢匹胺（CPM）进行了比较。结果发现，在正常体温以及较低温度下，CZON在这些头孢菌素中对MRS的活性最强。
