Department of Plastic and Reconstructive Surgery-Hand Surgery Unit, Azienda 'Ospedali Riuniti', 60126 Ancona, Italy.
Clinical Orthopaedics, Department of Clinical and Molecular Science, Polytechnic University of Marche, 60126 Ancona, Italy.
Int J Mol Sci. 2021 Sep 22;22(19):10197. doi: 10.3390/ijms221910197.
Osteoarthritis (OA) is a chronic debilitating disorder causing pain and gradual degeneration of weight-bearing joints with detrimental effects on cartilage volume as well as cartilage damage, generating inflammation in the joint structure. The etiology of OA is multifactorial. Currently, therapies are mainly addressing the physical and occupational aspects of osteoarthritis using pharmacologic pain treatment and/or surgery to manage the symptomatology of the disease with no specific regard to disease progression or prevention. Herein, we highlight alternative therapeutics for OA specifically considering innovative and encouraging translational methods with the use of adipose mesenchymal stem cells.
骨关节炎（OA）是一种慢性致残性疾病，会引起承重关节疼痛和逐渐退化，对软骨体积以及软骨损伤产生不利影响，导致关节结构炎症。OA 的病因是多因素的。目前，治疗方法主要是通过药物治疗疼痛和/或手术来解决骨关节炎的身体和职业方面的问题，以管理疾病的症状，但没有特别关注疾病的进展或预防。在这里，我们特别强调 OA 的替代疗法，考虑使用脂肪间充质干细胞的创新和有希望的转化方法。
