International Research Center for Marine Biosciences at Shanghai Ocean University, Ministry of Science and Technology, Shanghai, P.R. China.
National Pathogen Collection Center for Aquatic Animals, Shanghai, P.R. China.
Histol Histopathol. 2018 Jul;33(7):639-653. doi: 10.14670/HH-11-955. Epub 2017 Dec 15.
Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly incriminated in the physio-pathological mechanism of KOA. While conventional therapies result in unfavorable clinical outcomes, regenerative cell therapies have shown great promise in articular cartilage regeneration. Adipose-derived stem cells (ASCs) appear to be an ideal alternative to bone-marrow derived stem cells (BMSCs) and autologous chondrocytes, due to their lower immunogenicity, richer source and easier acquisition. Since the first case report in 2011, ASCs have demonstrated safety and efficacy for articular cartilage regeneration in several phase I/II clinical trials. However, different levels of abnormality were found in the regenerated cartilage for most of the patients. A large portion of recent publications investigated different optimization strategies to improve the therapeutic function of ASCs, including cell source selection, preconditioning and co-delivery. Herein, we give an update on the latest research progress on ASCs, with a focus on the most promising optimization strategies for ASC-based therapy.
膝骨关节炎（KOA）是世界上最常见的与残疾相关的进行性关节疾病。作为一种慢性疾病，KOA 具有多因素病因。然而，由于关节软骨内在的组织低血管化和低细胞性，其自我修复能力差，似乎直接涉及到 KOA 的生理病理机制。虽然传统疗法导致临床结果不理想，但再生细胞疗法在关节软骨再生方面显示出巨大的前景。脂肪来源的干细胞（ASCs）由于其较低的免疫原性、更丰富的来源和更容易获得，似乎是骨髓来源的干细胞（BMSCs）和自体软骨细胞的理想替代品。自 2011 年首例病例报告以来，ASCs 在几项 I/II 期临床试验中已被证明对关节软骨再生的安全性和有效性。然而，对于大多数患者，再生软骨中发现了不同程度的异常。最近的大量出版物研究了不同的优化策略，以提高 ASCs 的治疗功能，包括细胞源选择、预处理和共递运。本文重点介绍了基于 ASC 的治疗最有前途的优化策略，综述了 ASCs 的最新研究进展。
