Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 Rue St Denis, Montreal, QC H2X 0A9, Canada.
Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, QC H1T 2M4, Canada.
Int J Mol Sci. 2021 Sep 26;22(19):10366. doi: 10.3390/ijms221910366.
A cell should deal with the changing external environment or the neighboring cells. Inevitably, the cell surface receives and transduces a number of signals to produce apt responses. Typically, cell surface receptors are activated, and during this process, the subplasmalemmal actin cytoskeleton is often rearranged. An intriguing point is that some signaling enzymes and ion channels are physically associated with the actin cytoskeleton, raising the possibility that the subtle changes of the local actin cytoskeleton can, in turn, modulate the activities of these proteins. In this study, we reviewed the early and new experimental evidence supporting the notion of actin-regulated enzyme and ion channel activities in various cell types including the cells of immune response, neurons, oocytes, hepatocytes, and epithelial cells, with a special emphasis on the Ca signaling pathway that depends on the synthesis of inositol 1,4,5-trisphosphate. Some of the features that are commonly found in diverse cells from a wide spectrum of the animal species suggest that fine-tuning of the activities of the enzymes and ion channels by the actin cytoskeleton may be an important strategy to inhibit or enhance the function of these signaling proteins.
细胞需要应对不断变化的外部环境或邻近的细胞。不可避免地，细胞表面会接收和转导许多信号，以产生适当的反应。通常，细胞表面受体被激活，在此过程中，亚质膜肌动蛋白细胞骨架经常被重新排列。一个有趣的观点是，一些信号酶和离子通道与肌动蛋白细胞骨架物理相关，这增加了这样一种可能性，即局部肌动蛋白细胞骨架的细微变化可以反过来调节这些蛋白质的活性。在本研究中，我们回顾了早期和新的实验证据，支持了在各种细胞类型（包括免疫反应细胞、神经元、卵母细胞、肝细胞和上皮细胞）中肌动蛋白调节酶和离子通道活性的观点，特别强调了依赖肌醇 1,4,5-三磷酸合成的 Ca 信号通路。从动物物种的广泛范围中发现的各种不同细胞中共同存在的一些特征表明，肌动蛋白细胞骨架对酶和离子通道活性的精细调节可能是抑制或增强这些信号蛋白功能的重要策略。
