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子宫内膜异位症:流行病学、分类、发病机制、治疗和遗传学(文献综述)。

Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature).

机构信息

Laboratory of Cancer Genetics, Department of Pathology, Polish Mother's Memorial Hospital Research Institute, Rzgowska 281/289, 93-338 Lodz, Poland.

Department of Operative Gynaecology and Oncological Gynaecology, Polish Mother's Memorial Hospital Research Institute, Rzgowska 281/289, 93-338 Lodz, Poland.

出版信息

Int J Mol Sci. 2021 Sep 29;22(19):10554. doi: 10.3390/ijms221910554.

Abstract

Endometriosis is a "mysterious" disease and its exact cause has not yet been established. Among the etiological factors, congenital, environmental, epigenetic, autoimmune and allergic factors are listed. It is believed that the primary mechanism of the formation of endometriosis foci is retrograde menstruation, i.e., the passage of menstrual blood through the fallopian tubes into the peritoneal cavity and implantation of exfoliated endometrial cells. However, since this mechanism is also observed in healthy women, other factors must also be involved in the formation of endometriosis foci. Endometriosis is in many women the cause of infertility, chronic pain and the deterioration of the quality of life. It also represents a significant financial burden on health systems. The article presents a review of the literature on endometriosis-a disease affecting women throughout the world.

摘要

子宫内膜异位症是一种“神秘”的疾病,其确切病因尚未确定。在病因学因素中,列出了先天性、环境、表观遗传、自身免疫和过敏因素。人们认为,子宫内膜异位症病灶形成的主要机制是逆行性月经,即经血通过输卵管进入腹腔并植入脱落的子宫内膜细胞。然而,由于这种机制也存在于健康女性中,因此其他因素也必须参与子宫内膜异位症病灶的形成。子宫内膜异位症是许多女性不孕、慢性疼痛和生活质量恶化的原因。它也给卫生系统带来了巨大的经济负担。本文对影响全球女性的子宫内膜异位症疾病的文献进行了综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c2/8508982/2e858e092075/ijms-22-10554-g001.jpg

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