Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki 761-0793, Japan.
Int J Mol Sci. 2021 Sep 30;22(19):10630. doi: 10.3390/ijms221910630.
Hepatocellular carcinoma (HCC) is a common liver malignancy with high morbidity and poor prognosis. Long non-coding RNAs (lncRNAs) are involved in crucial biological processes of tumorigenesis and progression, and play four major regulatory roles, namely signal, decoy, guide, and scaffold, to regulate gene expression. Through these processes, lncRNAs can target microRNAs (miRNAs) to form lncRNA and miRNA networks, which regulate cancer cell proliferation, metastasis, drug resistance, and the tumor microenvironment. Here, we summarize the multifaceted functions of lncRNA and miRNA networks in the pathogenesis of HCC, the potential use of diagnostic or prognostic biomarkers, and novel therapeutic targets in HCC. This review also highlights the regulatory effects of lncRNA and miRNA networks in the tumor microenvironment of HCC.
肝细胞癌（HCC）是一种常见的肝脏恶性肿瘤，发病率高，预后差。长链非编码 RNA（lncRNA）参与肿瘤发生和发展的关键生物学过程，发挥四种主要的调控作用，即信号、诱饵、指导和支架，以调节基因表达。通过这些过程，lncRNA 可以靶向 microRNAs（miRNA）形成 lncRNA 和 miRNA 网络，调节癌细胞的增殖、转移、耐药性和肿瘤微环境。在这里，我们总结了 lncRNA 和 miRNA 网络在 HCC 发病机制中的多方面功能，以及其在 HCC 诊断或预后生物标志物和新治疗靶点中的潜在应用。本综述还强调了 lncRNA 和 miRNA 网络在 HCC 肿瘤微环境中的调节作用。
