Affronti Alessandro, Sandoval Elena, Muro Anna, Hernández-Campo Jose, Quintana Eduard, Pereda Daniel, Alcocer Jorge, Pruna-Guillen Robert, Castellà Manuel
Cardiovascular Surgery, Hospital Clínic, University of Barcelona, c/Villarroel 170 Esc 1 5th Floor, 08036 Barcelona, Spain.
J Clin Med. 2021 Sep 22;10(19):4288. doi: 10.3390/jcm10194288.
Surgical re-explorations represent 3-5% of all cardiac surgery. Concerns regarding mortality and major morbidity of re-explorations in the intensive care unit (ICU) setting exist. We sought to investigate whether they may have different outcomes compared with those performed in the operating room (OR). Single center retrospective review of patients who underwent mediastinal re-exploration in the ICU or in the OR after cardiac surgery. Mediastinal re-explorations were also classified as: "planned" and "unplanned". Primary outcome was 30-day mortality, secondary outcomes include deep sternal wound infection (DSWI), sepsis, ICU and hospital length of stay, prolonged intubation (>72 h), tracheostomy, pneumonia, acute kidney injury requiring dialysis and stroke. Between 2010 and 2019, 195 of 7263 patients (2.7%) underwent mediastinal re-exploration after cardiac surgery. More patients in the ICU group experienced two or more re-explorations (30.3% vs. 2.3%, < 0.001), a higher incidence of postoperative pneumonia (22% vs. 7%, = 0.004), prolonged intubation (46.8% vs. 19.8%, < 0.001) and longer hospital stay (30.3 ± 34.2 vs. 20.8 ± 18.3 days, = 0.014). There were no differences in mortality between ICU and OR (16.5% vs. 13.9%, = 0.24) nor in sepsis (14.7% vs. 7%, = 0.91) and DSWI rates (1.8% vs. 1.2%, = 0.14). Re-explorations in the ICU were not associated with increased mortality, sepsis and mediastinitis rate.
再次手术探查占所有心脏手术的3%-5%。人们对重症监护病房(ICU)环境下再次手术探查的死亡率和主要并发症存在担忧。我们试图研究与在手术室(OR)进行的再次手术探查相比,其结果是否有所不同。对心脏手术后在ICU或OR接受纵隔再次手术探查的患者进行单中心回顾性研究。纵隔再次手术探查也分为“计划性”和“非计划性”。主要结局是30天死亡率,次要结局包括深部胸骨伤口感染(DSWI)、脓毒症、ICU住院时间和住院时间、长时间插管(>72小时)、气管切开术、肺炎、需要透析的急性肾损伤和中风。2010年至2019年期间,7263例患者中有195例(2.7%)在心脏手术后接受了纵隔再次手术探查。ICU组更多患者经历了两次或更多次再次手术探查(30.3%对2.3%,<0.001),术后肺炎发生率更高(22%对7%,=0.004),长时间插管(46.8%对19.8%,<0.001)以及住院时间更长(30.3±34.2天对20.8±18.3天,=0.014)。ICU和OR之间的死亡率(16.5%对13.9%,=0.24)、脓毒症(14.7%对7%,=0.91)和DSWI发生率(1.8%对1.2%,=0.14)没有差异。在ICU进行的再次手术探查与死亡率、脓毒症和纵隔炎发生率增加无关。