Avitan Iska, Halperin Yudit, Saha Trishna, Bloch Naamah, Atrahimovich Dana, Polis Baruh, Samson Abraham O, Braitbard Ori
Bioinformatics Department, Jerusalem College of Technology, Jerusalem 9548311, Israel.
Azrieli Faculty of Medicine, Bar Ilan University, Safed 1311502, Israel.
J Clin Med. 2021 Sep 24;10(19):4360. doi: 10.3390/jcm10194360.
Alzheimer's disease (AD) is often comorbid with other pathologies. First, we review shortly the diseases most associated with AD in the clinic. Then we query PubMed citations for the co-occurrence of AD with other diseases, using a list of 400 common pathologies. Significantly, AD is found to be associated with schizophrenia and psychosis, sleep insomnia and apnea, type 2 diabetes, atherosclerosis, hypertension, cardiovascular diseases, obesity, fibrillation, osteoporosis, arthritis, glaucoma, metabolic syndrome, pain, herpes, HIV, alcoholism, heart failure, migraine, pneumonia, dyslipidemia, COPD and asthma, hearing loss, and tobacco smoking. Trivially, AD is also found to be associated with several neurodegenerative diseases, which are disregarded. Notably, our predicted results are consistent with the previously published clinical data and correlate nicely with individual publications. Our results emphasize risk factors and promulgate diseases often associated with AD. Interestingly, the comorbid diseases are often degenerative diseases exacerbated by reactive oxygen species, thus underlining the potential role of antioxidants in the treatment of AD and comorbid diseases.
阿尔茨海默病（AD）常与其他病理状况合并存在。首先，我们简要回顾一下临床上与AD关联最为密切的疾病。然后，我们使用一份包含400种常见病理状况的列表，在PubMed数据库中查询AD与其他疾病同时出现的文献引用情况。值得注意的是，发现AD与精神分裂症和精神病、睡眠失眠和呼吸暂停、2型糖尿病、动脉粥样硬化、高血压、心血管疾病、肥胖症、震颤、骨质疏松症、关节炎、青光眼、代谢综合征、疼痛、疱疹、HIV、酗酒、心力衰竭、偏头痛、肺炎、血脂异常、慢性阻塞性肺疾病（COPD）和哮喘、听力损失以及吸烟有关。显而易见，AD还与几种神经退行性疾病有关联，但这些在此不予考虑。值得注意的是，我们的预测结果与先前发表的临床数据一致，并且与个别出版物的结果高度相关。我们的结果强调了与AD相关的风险因素和常见疾病。有趣的是，这些合并症往往是由活性氧加剧的退行性疾病，从而凸显了抗氧化剂在AD及合并症治疗中的潜在作用。
