Rydnert J
Prostaglandins. 1986 Jul;32(1):57-61. doi: 10.1016/0090-6980(86)90143-7.
A quantitative determination of the pharmacological effect of the prostaglandin analogue 16-phenoxy-omega-17,18,19,20-tetranor-PGE2 methyl sulfonylamide (16-phenoxy-PGE2) and the natural prostaglandin E2 has been made in vivo upon the human myometrium during early pregnancy. The method for the investigation, hysterometry, is based upon the concept that mechanical distension of smooth muscle induces contraction. The contractile response was recorded under basic conditions and during intravenous infusion of the active agent. It was found that the analogue had a 'potency' similar to or slightly more pronounced than the natural prostaglandin E2 when the comparison was made on a microgram basis.
已对前列腺素类似物16-苯氧基-ω-17,18,19,20-四去甲-PGE2甲磺酰胺（16-苯氧基-PGE2）和天然前列腺素E2在早孕期对人子宫肌层的药理作用进行了体内定量测定。该研究方法，即子宫测压法，基于平滑肌的机械扩张会诱导收缩这一概念。在基础条件下以及静脉输注活性剂期间记录收缩反应。结果发现，当以微克为基础进行比较时，该类似物的“效力”与天然前列腺素E2相似或略强。
