Rydnert J, Joelsson I
Acta Obstet Gynecol Scand. 1985;64(7):577-82. doi: 10.3109/00016348509156366.
Hysterometry has been used to evaluate the effect on the human myometrium in vivo during early pregnancy of the naturally occurring prostaglandins E2 and F2 alpha. The hystermetric technique is based upon the fact that mechanical distension of smooth muscle induces contraction. According to the analysis of the contractile responses, the effects of the agents have been determined quantitatively. The drug effects have been characterized by changes in myometrial response between registrations under basic conditions and during the infusion of the active agent, respectively. It was found that when these drugs were given in the doses usually employed in clinical practice, the effect on contractility of the PGF2 alpha compound was more pronounced than that of the PGE2. However, when describing the results on a microgram basis, the PGE2 was confirmed to be more potent than the PGF2 alpha by a factor of up to 7-8.
子宫测量术已被用于评估在妊娠早期，天然存在的前列腺素E2和F2α对人体子宫肌层的体内影响。子宫测量技术基于平滑肌的机械扩张会诱发收缩这一事实。根据对收缩反应的分析，已对这些药物的作用进行了定量测定。药物作用分别通过基础条件下和活性药物输注期间记录的子宫肌层反应变化来表征。结果发现，当以临床实践中常用的剂量给予这些药物时，PGF2α化合物对收缩性的影响比PGE2更明显。然而，以微克为单位描述结果时，证实PGE2的效力比PGF2α高7至8倍。
