Hsu Kun-Jung, Hsiao Szu-Yu, Chen Ping-Ho, Chen Han-Sheng, Chen Chun-Ming
School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
J Clin Med. 2021 Sep 29;10(19):4480. doi: 10.3390/jcm10194480.
Medication-related osteonecrosis of the jaw (MRONJ) occurs after exposure to medication (antiresorptive or antiangiogenic agents) for bone-related complications. It is more common in the mandible than in the maxilla. The present study investigated maxillary MRONJ in elderly patients through a meta-analysis.
Keywords, including "MRONJ", "maxilla", and "surgery", were entered into databases, including Embase, PubMed/MEDLINE, Cochrane Library, and ProQuest, which were searched systematically.
Investigating 77 studies, we found that 18 (2 case reports and 16 case series) papers conformed to the standards. The results revealed a 2.6:1 female-to-male ratio of disease occurrence. The average age of patients was 70.6 ± 5.5 years, and most patients were in the third stage (43.6%). The average time of medication usage was 50.0 ± 20.1 months. The pooled proportion of clinical efficacy of surgery was 86%.
To prevent and manage MRONJ, all elderly patients should maintain proper oral hygiene and receive dental examinations regularly. Risk assessment and safety management of MRONJ should be performed by medical teams.
颌骨药物相关性骨坏死（MRONJ）发生于因骨相关并发症而暴露于药物（抗吸收或抗血管生成剂）之后。其在下颌骨比在上颌骨更常见。本研究通过荟萃分析调查老年患者的上颌骨MRONJ。
将包括“MRONJ”、“上颌骨”和“手术”等关键词输入Embase、PubMed/MEDLINE、Cochrane图书馆和ProQuest等数据库，并进行系统检索。
在调查的77项研究中，我们发现18篇（2篇病例报告和16篇病例系列）论文符合标准。结果显示疾病发生的男女比例为2.6:1。患者的平均年龄为70.6±5.5岁，大多数患者处于第三阶段（43.6%）。平均用药时间为50.0±20.1个月。手术临床疗效的合并比例为86%。
为预防和管理MRONJ，所有老年患者应保持良好的口腔卫生并定期接受牙科检查。应由医疗团队进行MRONJ的风险评估和安全管理。
