Rossi M R, Boccazzi A, Capuccilli M L, Crosignani R, Gornati G, Masera G
Chemioterapia. 1986 Aug;5(4):283-4.
Ceftriaxone (CFX) is a new third-generation cephalosporin with interesting characteristics as regards both its antibacterial spectrum and kinetics which make it potentially useful in the empiric treatment of infections in neutropenic cancer patients. However, since its kinetic characteristics in children with leukemia are not known and its pharmacokinetics are reported to be altered in such patients, we studied ceftriaxone's activity in ten leukemic children with fever and neutropenia. Our findings seem to be confirm the potential efficacy of the drug also in this particular type of patient.
头孢曲松（CFX）是一种新型第三代头孢菌素，其抗菌谱和动力学特性都很有趣，这使其在经验性治疗中性粒细胞减少的癌症患者感染方面具有潜在用途。然而，由于其在白血病患儿中的动力学特性尚不清楚，且据报道此类患者的药代动力学有所改变，我们研究了头孢曲松在10名发热且中性粒细胞减少的白血病患儿中的活性。我们的研究结果似乎证实了该药物在这类特殊患者中也具有潜在疗效。
