Stutchfield P R, White R H, Cameron A H, Thompson R A, Mackintosh P, Wells L
Clin Nephrol. 1986 Sep;26(3):150-6.
Two related male patients with mesangiocapillary glomerulonephritis (MCGN) are described demonstrated by renal biopsy, inherited as an X-linked disorder. Family investigations failed to reveal any underlying immunological defects or a marker for the female carrier state. The age at diagnosis, the result of discovery of proteinuria on routine urine testing during infancy, is earlier than in any other reported cases of MCGN. This raises the possibility that this variety of MCGN may develop in utero and be detectable by alpha-fetoprotein maternal screening.
本文描述了两名经肾活检证实患有系膜毛细血管性肾小球肾炎（MCGN）的相关男性患者，该病为X连锁疾病。家族调查未发现任何潜在的免疫缺陷或女性携带者状态的标志物。诊断时的年龄，即在婴儿期常规尿检发现蛋白尿的结果，比其他任何报道的MCGN病例都要早。这增加了这种类型的MCGN可能在子宫内就已发病并可通过母体甲胎蛋白筛查检测到的可能性。
