Department of Human Nutrition, University of Alabama, Tuscaloosa, Alabama, USA.
Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
J Nutr Gerontol Geriatr. 2021 Oct-Dec;40(4):304-312. doi: 10.1080/21551197.2021.1988028. Epub 2021 Oct 13.
Lycopene exhibits neuroprotective properties due to its antioxidant and anti-inflammatory functionality. As watermelon is a rich source of lycopene, pasteurized watermelon juice provides lycopene in its most bioavailable form. This study examined relationships between circulating lycopene, cognitive performance, and biomarkers of oxidative stress and inflammation in response to pasteurized 100% watermelon juice supplementation. A placebo-controlled, randomized, double-blind, crossover trial was conducted with postmenopausal women ( = 16, 60 + 4.1 years). Participants consumed two 360 mL servings of pasteurized 100% watermelon juice or a placebo beverage for 4 weeks. Fasting blood samples were collected, and cognitive tests were administered to assess various neurocognitive domains. Statistical analyses included mixed models and Spearman correlations. Serum lycopene exhibited a significant treatment effect ( = 0.002) with a mean increase of 81%. However, this increase was not associated with changes in oxidative stress, inflammation, or cognitive function. Additional research is warranted to determine dose-durational effects for promoting cognition.
番茄红素具有抗氧化和抗炎功能，表现出神经保护特性。由于西瓜是番茄红素的丰富来源，因此巴氏杀菌西瓜汁以其最具生物利用度的形式提供了番茄红素。本研究考察了摄入巴氏杀菌 100%西瓜汁后循环番茄红素与认知表现以及氧化应激和炎症生物标志物之间的关系。对绝经后妇女（ = 16，60 + 4.1 岁）进行了一项安慰剂对照、随机、双盲、交叉试验。参与者连续 4 周每天饮用两份 360 毫升巴氏杀菌 100%西瓜汁或安慰剂饮料。采集空腹血样，并进行认知测试以评估各种神经认知领域。统计分析包括混合模型和 Spearman 相关性。血清番茄红素表现出显著的治疗效果（ = 0.002），平均增加 81%。然而，这种增加与氧化应激、炎症或认知功能的变化无关。需要进一步的研究来确定促进认知的剂量-持续时间效应。
