Vascular Surgery Unit, Department of Cardiothoracic and Vascular Surgery, Medical School, University of Crete, Heraklion, Crete, Greece.
Vascular Surgery Unit, Department of Cardiothoracic and Vascular Surgery, Medical School, University of Crete, Heraklion, Crete, Greece.
Ann Vasc Surg. 2022 Feb;79:438.e1-438.e4. doi: 10.1016/j.avsg.2021.07.033. Epub 2021 Oct 10.
Vaccine Induced Thrombotic Thrombocytopenia (VITT) is a rare complication following ChAdOx1 (AstraZeneca) vaccination. Venous thrombosis in unusual sites such as splachnic or intracranial thrombosis, is the commonest manifestation.
We report a 35-year-old male patient who presented with acute left leg ischemia and thrombocytopenia 11-days after vaccination requiring emergent thrombectomy. During work-up, a localized thrombus was detected in the left carotid bifurcation mandating carotid thrombectomy. Localized right iliac thrombus causing a non-limiting flow stenosis was treated conservatively. The platelet aggregating capacity of patient's plasma was confirmed in a functional assay, thereby establishing VITT.
To the best of our knowledge this is the first case presenting multiple arterial thromboses requiring surgical treatment after ChAdOx1 vaccination.
接种 ChAdOx1（阿斯利康）疫苗后会发生血栓性血小板减少症（VITT），这是一种罕见的并发症。ChAdOx1 疫苗接种后最常见的表现是脾或颅内静脉血栓等不常见部位的静脉血栓形成。
我们报告了一例 35 岁男性患者，该患者在接种疫苗后 11 天出现急性左下肢缺血和血小板减少症，需要紧急进行血栓切除术。在检查过程中，在左侧颈动脉分叉处发现局部血栓，需要进行颈动脉血栓切除术。右侧髂内血栓导致非限制性血流狭窄，采用保守治疗。通过功能测定证实了患者血浆的血小板聚集能力，从而确定了 VITT。
据我们所知，这是首例接种 ChAdOx1 疫苗后出现多处动脉血栓形成并需要手术治疗的病例。
