Palmer David, Davis Lauren, Sivaloganathan Helena, Chevassut Timothy
Royal Sussex County Hospitals, University Hospitals Sussex, Brighton BN2 5BE, UK.
Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9PS, UK.
Case Rep Hematol. 2022 Sep 30;2022:4742639. doi: 10.1155/2022/4742639. eCollection 2022.
The significant impact of the COVID-19 pandemic has resulted in a worldwide effort to develop effective vaccines. In the United Kingdom, the COVID-19 vaccine development and roll-out has been overwhelmingly successful in reducing infections and deaths. However, case reports have emerged of a rare syndrome of vaccine-induced immune thrombocytopenia and thrombosis (VITT), as well as cases of immune thrombocytopenia (ITP). This has necessitated a better understanding of these conditions. However, as both VITT and "vaccine-associated ITP" are emerging conditions, evidence on the clinical features, epidemiology, and management is still evolving. Subsequently, with the initiation of the COVID-19 vaccine booster program, it has become increasingly important to continue to collect accurate data on post-COVID-19 vaccine complications to aid with their prompt recognition and management. In this case series, we report on the presentations and management of seven cases of post-COVID-19 vaccine-related immune-mediated complications which occurred at our center between the months of March and July 2021.
新冠疫情的重大影响促使全球致力于研发有效的疫苗。在英国，新冠疫苗的研发和推广在减少感染和死亡方面取得了巨大成功。然而，出现了关于疫苗诱导的免疫性血小板减少症和血栓形成（VITT）这一罕见综合征的病例报告，以及免疫性血小板减少症（ITP）的病例。这就需要更好地了解这些病症。然而，由于VITT和“疫苗相关ITP”都是新出现的病症，关于其临床特征、流行病学和管理的证据仍在不断演变。随后，随着新冠疫苗加强针计划的启动，持续收集关于新冠疫苗接种后并发症的准确数据以帮助及时识别和管理这些并发症变得越来越重要。在本病例系列中，我们报告了2021年3月至7月期间在我们中心发生的7例与新冠疫苗相关的免疫介导并发症的表现和管理情况。
