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卡介苗膀胱内治疗继发牛分枝杆菌致霉菌性动脉瘤:一例报告

Mycobacterium Bovis Causing Mycotic Aneurysm Secondary to Intravesical Treatment with Bacillus Calmette-Guérin: A Case Report.

作者信息

Zaza Sarah I, Ghasemzadeh Ali, Bennett Kyla M

机构信息

Division of Vascular Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI.

出版信息

Ann Vasc Surg. 2022 Feb;79:437.e1-437.e6. doi: 10.1016/j.avsg.2021.07.032. Epub 2021 Oct 10.

Abstract

Bacillus Calmette-Guerin (BCG) is a live, attenuated strain of Mycobacterium bovis that is used in the treatment of non-muscle invasive bladder cancer (NMIBC). Vascular complications, including mycotic aneurysms, after BCG therapy are exceedingly rare. In this patient population, the diagnosis of mycotic aneurysms can be delayed or missed due to their non-specific clinical and radiologic presentation. Literature review reveals management of mycotic aneurysms attributable to BCG therapy is widely varied. CASE REPORT: We report a patient who presented with mycotic aneurysm formation secondary to BCG treatment for bladder cancer that was repaired with in-line reconstruction utilizing cryoartery and buttressed with omental flap. We suggest this as an alternative treatment to in-line prosthetic graft or extra-anatomic reconstruction.

摘要

卡介苗(BCG)是一种减毒活牛分枝杆菌菌株,用于治疗非肌肉浸润性膀胱癌(NMIBC)。卡介苗治疗后的血管并发症,包括霉菌性动脉瘤,极为罕见。在这一患者群体中,霉菌性动脉瘤的诊断可能会因非特异性的临床和放射学表现而延迟或漏诊。文献综述显示,卡介苗治疗所致霉菌性动脉瘤的治疗方法差异很大。病例报告:我们报告一例患者,因膀胱癌接受卡介苗治疗继发霉菌性动脉瘤形成,采用冷冻动脉原位重建并大网膜瓣支撑进行修复。我们建议将此作为原位人工血管移植或解剖外重建的替代治疗方法。

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