Aerosp Med Hum Perform. 2021 Sep 1;92(9):734-737. doi: 10.3357/AMHP.5759.2021.
The following case report describes the first known case of McLeod Syndrome in a commercial airline pilot. The case describes a 56-yr-old experienced pilot who showed a slow and subtle decline in cognitive function and muscle control in the cockpit. On further examination, the pilots erratic behavior and movement along with lab abnormalities pointed toward McLeod Syndrome. The pilot was recommended for evaluation by his fellow crewmembers due to his fidgetiness, clumsiness, and lack of focus during critical portions of flight. The pilot reported having a long-standing history of elevated CK levels. Further lab investigations revealed acanthocytes on blood smear while neurological evaluation detected chorea. The combination of clinical and laboratory features along with genetic test results were all consistent with McLeod Syndrome. The case highlights how subtle behavioral and motor coordination changes can be a warning sign for an underlying progressive neurological disorder that requires further workup and referral. .
以下病例报告描述了首例商业航空公司飞行员中的 McLeod 综合征。该病例描述了一位 56 岁经验丰富的飞行员在驾驶舱中表现出认知功能和肌肉控制能力的缓慢而微妙的下降。进一步检查发现，飞行员的行为异常和运动以及实验室异常表明存在 McLeod 综合征。由于飞行员在飞行关键阶段的烦躁不安、笨拙和注意力不集中，他的同事建议对他进行评估。飞行员报告说他的 CK 水平长期升高。进一步的实验室检查显示血涂片上有棘形红细胞，而神经学评估则发现舞蹈病。临床和实验室特征以及基因检测结果的结合均符合 McLeod 综合征。该病例突出了微妙的行为和运动协调变化如何成为潜在进行性神经障碍的警告信号，需要进一步检查和转介。。
