腰大肌横截面积与 BMI 之间的非线性关系：新观察及其对 Roux-en-Y 胃旁路手术后糖尿病缓解的启示。
The Nonlinear Relationship Between Psoas Cross-sectional Area and BMI: A New Observation and Its Insights Into Diabetes Remission After Roux-en-Y Gastric Bypass.
机构信息
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, and Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
出版信息
Diabetes Care. 2021 Dec;44(12):2783-2786. doi: 10.2337/dc20-2907. Epub 2021 Oct 13.
OBJECTIVE
To explore the potential relevance of muscle mass as a variable contributor to BMI in limitations on BMI-based predictions of diabetes remission (DR) after Roux-en-Y gastric bypass (RYGB).
RESEARCH DESIGN AND METHODS
We evaluated the relationship between muscle mass and BMI in 501 patients with type 2 diabetes mellitus and overweight or obesity, of whom 186 patients who underwent RYGB were studied for determination of the role of baseline muscle mass and BMI in predicting DR. Muscle mass was assessed by estimated fat-free mass index (eFFMI) and psoas cross-sectional area (CSA).
RESULTS
A nonlinear relationship existed between psoas CSA and BMI, whereas psoas CSA showed a highly positive correlation with eFFMI. Baseline psoas CSA and eFFMI were better than BMI for predicting 1- and 5-year DR.
CONCLUSIONS
The nonlinear relationship between muscle mass and BMI may partially contribute to BMI limitations in predicting DR after RYGB.
目的
探讨肌肉质量作为 BMI 变量对 Roux-en-Y 胃旁路术（RYGB）后基于 BMI 的糖尿病缓解（DR）预测的限制的潜在相关性。
研究设计和方法
我们评估了 501 例 2 型糖尿病和超重或肥胖患者的肌肉质量与 BMI 之间的关系，其中 186 例接受 RYGB 的患者被研究，以确定基线肌肉质量和 BMI 在预测 DR 中的作用。肌肉质量通过估计无脂肪质量指数（eFFMI）和腰大肌横截面积（CSA）进行评估。
结果
腰大肌 CSA 与 BMI 之间存在非线性关系，而腰大肌 CSA 与 eFFMI 呈高度正相关。基线腰大肌 CSA 和 eFFMI 比 BMI 更能预测 1 年和 5 年的 DR。
结论
肌肉质量与 BMI 之间的非线性关系可能部分导致 RYGB 后 BMI 在预测 DR 方面的局限性。
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