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电针激活神经元以关闭炎症。

Electroacupuncture activates neurons to switch off inflammation.

出版信息

Nature. 2021 Oct;598(7882):573-574. doi: 10.1038/d41586-021-02714-0.

DOI:10.1038/d41586-021-02714-0
PMID:34646023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9628694/
Abstract

Neurons that express a specific molecular marker are activated by ‘electroacupuncture’ stimulation. They can then mediate the treatment’s anti-inflammatory effects in a mouse model of the inflammatory condition sepsis.

摘要

表达特定分子标记的神经元会被“电针”刺激激活。然后，它们可以在炎症性疾病败血症的小鼠模型中介导治疗的抗炎作用。

相似文献

[1]
Electroacupuncture activates neurons to switch off inflammation.

Nature. 2021-10

[2]
Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation.

BMC Complement Altern Med. 2008-5-12

[3]
[The action of medullary tail-flick related neurons in electroacupuncture analgesia].

Sheng Li Xue Bao. 1993-6

[4]
Electroacupuncture Stimulation Suppresses Postoperative Inflammatory Response and Hippocampal Neuronal Injury.

Mediators Inflamm. 2022

[5]
Dopamine mediates vagal modulation of the immune system by electroacupuncture.

Nat Med. 2014-2-23

[6]
Electroacupuncture induces Fos expression in the nucleus tractus solitarius via cholecystokinin A receptor signaling in rats.

Neurol Res. 2010-2

[7]
Electroacupuncture induces c-Fos expression in the rostral ventrolateral medulla and periaqueductal gray in cats: relation to opioid containing neurons.

Brain Res. 2004-12-24

[8]
[The significance of "A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis" published in for acupuncture research].

Zhen Ci Yan Jiu. 2022-1-25

[9]
Low-frequency electroacupuncture suppresses carrageenan-induced paw inflammation in mice via sympathetic post-ganglionic neurons, while high-frequency EA suppression is mediated by the sympathoadrenal medullary axis.

Brain Res Bull. 2008-3-28

[10]
Expression of c-Fos in arcuate nucleus induced by electroacupuncture: relations to neurons containing opioids and glutamate.

Brain Res. 2007-8-29

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[1]
Mechanism of electroacupuncture involve in lens-induced myopia guinea pigs by inhibiting wnt/β-catenin signaling pathway.

J Tradit Chin Med. 2025-8

[2]
Electroacupuncture Improves Sepsis-Induced Acute Gastrointestinal Injury: A Retrospective Propensity Score-Matched Cohort Study.

Health Sci Rep. 2025-7-21

[3]
Mechanisms and interventions in aneurysmal subarachnoid hemorrhage: Unraveling the role of inflammatory responses and cell death in early brain injury (Review).

Mol Med Rep. 2025-9

[4]
The Modulation of Neuroimmune Responses in Peripheral Inflammation.

J Inflamm Res. 2025-7-10

[5]
Exploring acupuncture: a promising adjunct in cancer care and symptom management.

Sci China Life Sci. 2025-7-4

[6]
Role of macrophages in neuroimmune regulation.

Front Immunol. 2025-6-18

[7]
Vagal stimulation ameliorates murine colitis by regulating SUMOylation.

Sci Transl Med. 2024-11-20

[8]
Calming the Wind: A Traditional Chinese Medicine Practitioner's Approach to Wartime Acute Stress Disorder Symptoms.

Curr Psychiatry Rep. 2024-11

[9]
Recent advances in acupuncture for pain relief.

Pain Rep. 2024-9-13

[10]
Therapeutically Fine-Tuning Autonomic Nervous System to Treat Sepsis: A New Perspective on the Immunomodulatory Effects of Acupuncture.

J Inflamm Res. 2024-7-5

本文引用的文献

[1]
A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis.

Nature. 2021-10

[2]
Parallel ascending spinal pathways for affective touch and pain.

Nature. 2020-11

[3]
Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture.

Neuron. 2020-8-12

[4]
Anatomical and clinical implications of vagal modulation of the spleen.

Neurosci Biobehav Rev. 2020-5

[5]
The emergence of transcriptional identity in somatosensory neurons.

Nature. 2020-1-8

[6]
Nerve Stimulation: Immunomodulation and Control of Inflammation.

Trends Mol Med. 2017-12

[7]
Neural regulation of immunity: molecular mechanisms and clinical translation.

Nat Neurosci. 2017-1-16

[8]
Dopamine mediates vagal modulation of the immune system by electroacupuncture.

Nat Med. 2014-2-23

[9]
β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system.

FASEB J. 2011-8-12

[10]
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.

Nat Neurosci. 2010-5-30

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