Center for Biomedical Science, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.
Center for Bioelectronic Medicine, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.
Nat Neurosci. 2017 Feb;20(2):156-166. doi: 10.1038/nn.4477. Epub 2017 Jan 16.
Studies bridging neuroscience and immunology have identified neural pathways that regulate immunity and inflammation. Recent research using methodological advances in molecular genetics has improved our understanding of the neural control of immunity. Here we outline mechanistic insights, focusing on translational relevance and conceptual developments. We also summarize findings from recent clinical studies of bioelectronic neuromodulation in inflammatory and autoimmune diseases.
神经科学和免疫学的交叉研究已经确定了调节免疫和炎症的神经通路。最近利用分子遗传学方法学进展的研究提高了我们对免疫神经控制的理解。在这里，我们概述了机制见解，重点关注转化相关性和概念发展。我们还总结了最近在炎症性和自身免疫性疾病的生物电子神经调节的临床研究中的发现。
