针刺对单纯性肥胖大鼠前列腺素 E 和瘦素水平的影响。

Effect of Acupuncture on Simple Obesity and Serum Levels of Prostaglandin E and Leptin in Sprague-Dawley Rats.

机构信息

Department of Traditional Chinese Medicine II Ward, Huaibei People's Hospital, Huaibei, 235000 Anhui Province, China.

Institute of Acupuncture and Meridians, Anhui University of Chinese Medicine, Hefei, 230038 Anhui Province, China.

出版信息

Comput Math Methods Med. 2021 Oct 4;2021:6730274. doi: 10.1155/2021/6730274. eCollection 2021.

AIM

The study is aimed at investigating the curative effect of acupuncture on simple obesity and its influence on serum levels of prostaglandin E and leptin in Sprague-Dawley (SD) rats.

METHODS

In the study, there are 50 male SD rats. We took 10 as healthy controls and fed 40 with a diet of high fat for 8 weeks. After the 40 rat model was established successfully, we fed 10 rats in the model group with a normal diet and treated 10 rats in the acupuncture group by acupuncture. During the experiment, the body fat and body length of rats were measured weekly, and Lee's index was calculated. After the treatment, the levels of leptin, prostaglandin E, C-reactive protein (CRP), triacylglycerol (TG), cholesterol (CHO), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were detected, and the liver fat morphology was observed by electron microscope.

RESULTS

Acupuncture significantly downregulated the serum levels of CRP, TG, CHO, LDL, leptin, and prostaglandin E and upregulated the serum levels of HDL in rats with simple obesity.

CONCLUSION

On basis of these results, it was found that acupuncture could boost fat metabolism and weight loss by inhibiting the production of leptin and prostaglandin E.

目的

本研究旨在探讨针刺治疗单纯性肥胖的疗效及其对 Sprague-Dawley（SD）大鼠前列腺素 E 和瘦素水平的影响。

方法

本研究共纳入 50 只雄性 SD 大鼠，其中 10 只为健康对照组，其余 40 只给予高脂饮食 8 周建立肥胖模型。成功建立 40 只大鼠模型后，其中 10 只模型组大鼠给予普通饮食，10 只针刺组大鼠给予针刺治疗。实验过程中每周测量大鼠体脂和体长，计算 Lee 指数。治疗结束后检测大鼠血清瘦素、前列腺素 E、C 反应蛋白（CRP）、三酰甘油（TG）、胆固醇（CHO）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）水平，电镜观察肝组织脂肪形态。