一家三级妇产医院中孕妇自身免疫性疾病的患病率：一项横断面调查及产科数据库回顾
Prevalence of autoimmune conditions in pregnant women in a tertiary maternity hospital: A cross-sectional survey and maternity database review.
作者信息
Lim Jacqueline R, Nielsen Timothy C, Dale Russell C, Jones Hannah F, Beech Amanda, Nassar Natasha, Lain Samantha J, Shand Antonia
机构信息
Sydney Medical School, The University of Sydney, Sydney, Australia.
Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
出版信息
Obstet Med. 2021 Sep;14(3):158-163. doi: 10.1177/1753495X20964680. Epub 2020 Nov 3.
BACKGROUND
Autoimmune conditions are associated with adverse pregnancy and offspring outcomes; however, the prevalence in pregnant women is not well understood. Estimates based on administrative data alone may underestimate prevalence.
METHODS
A cross-sectional survey of women attending a tertiary referral hospital for antenatal care in December 2018-February 2019 and review of the hospital's maternity database of women giving birth from October 2017-June 2018 to estimate autoimmune disease prevalence.
RESULTS
A total of 400 women completed surveys (78% response rate) and 41 (10.3%) reported an autoimmune disease, most commonly Hashimoto's thyroiditis (2.8%) and psoriasis (2.5%). From the maternity database, 112 of 2756 women giving birth (4.1%) had a recorded autoimmune disease, most commonly Hashimoto's thyroiditis (1.3%) followed by coeliac disease, Graves' disease, and immune thrombocytopenic purpura (all 0.4%).
CONCLUSION
Autoimmune disease prevalence in pregnant women is higher when self-reported and may be more common than previously reported using administrative data.
背景
自身免疫性疾病与不良妊娠及后代结局相关；然而，孕妇中该疾病的患病率尚不明确。仅基于行政数据的估计可能会低估患病率。
方法
对2018年12月至2019年2月在一家三级转诊医院接受产前检查的女性进行横断面调查，并回顾该医院2017年10月至2018年6月分娩女性的产科数据库，以估计自身免疫性疾病的患病率。
结果
共有400名女性完成调查（应答率为78%），41名（10.3%）报告患有自身免疫性疾病，最常见的是桥本甲状腺炎（2.8%）和银屑病（2.5%）。在产科数据库中，2756名分娩女性中有112名（4.1%）记录有自身免疫性疾病，最常见的是桥本甲状腺炎（1.3%），其次是乳糜泻、格雷夫斯病和免疫性血小板减少性紫癜（均为0.4%）。
结论
孕妇自身免疫性疾病的自我报告患病率较高，可能比之前使用行政数据报告的更为常见。
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