Seo Yun-Soo, Shin Na-Rea, Nam Hyeon Hwa, Song Jun-Ho, Cheol Moon Byeong, Choi Goya, Shin In-Sik, Kim Joong-Sun
Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine Naju-si Korea.
College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University Gwangju Korea.
Food Sci Nutr. 2021 Aug 6;9(10):5361-5369. doi: 10.1002/fsn3.2460. eCollection 2021 Oct.
is an animal-based medicine used traditionally in China, Japan, and Korea to treat hepatic disorders; it has been shown to possess various pharmacological effects such as antibacterial and antioxidant activities. In this study, we investigated the effects of . on a testosterone-induced benign prostatic hyperplasia (BPH) rat model. To establish the BPH model, the animals were administered a subcutaneous injection of testosterone daily for 28 days. . was administered by oral gavage at doses of 12.5, 25, and 50 mg/kg for 28 days, along with testosterone injection. . treatment markedly decreased the absolute and relative prostate weight of BPH animals. The levels of dihydrotestosterone was reduced in . -treated animals compared to those in the BPH animals. Histological analysis of the prostate showed that . treatment effectively suppressed the testosterone-induced hyperplasia of prostatic epithelial cells, which was accompanied by reductions in the PCNA and Ki-67 expressions in prostatic tissues. These results indicate that . effectively suppresses testosterone-induced development of BPH, and thus, is a potential therapeutic agent for BPH.
是一种传统上在中国、日本和韩国用于治疗肝脏疾病的动物源性药物；已显示其具有多种药理作用，如抗菌和抗氧化活性。在本研究中，我们研究了……对睾酮诱导的良性前列腺增生（BPH）大鼠模型的影响。为建立BPH模型，每天给动物皮下注射睾酮，持续28天。……与睾酮注射同时，以12.5、25和50mg/kg的剂量通过口服灌胃给药28天。……治疗显著降低了BPH动物的前列腺绝对重量和相对重量。与BPH动物相比，……治疗的动物中双氢睾酮水平降低。前列腺组织学分析表明，……治疗有效抑制了睾酮诱导的前列腺上皮细胞增生，同时前列腺组织中PCNA和Ki-67表达降低。这些结果表明，……有效抑制睾酮诱导的BPH发展，因此是BPH的潜在治疗药物。
