Cai Hongcai, Zhang Guowei, Yan Zechen, Shang Xuejun
Department of Andrology, Jinling Hospital Affiliated to Southern Medical University, Nanjing, Jiangsu 210002, China.
Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Evid Based Complement Alternat Med. 2018 Sep 30;2018:5367814. doi: 10.1155/2018/5367814. eCollection 2018.
Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. () capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate the therapeutic effect of capsule on testosterone propionate- (TP-) induced BPH in rats. Fifty male Sprague-Dawley rats were randomly divided into 5 groups: sham control, BPH model, high and low dose of , and finasteride as a positive control group. All groups were treated with appropriate drugs/normal saline for 28 consecutive days. Prostate weights were recorded; histopathological changes and content of IL-8, TNF-, DHT, SOD, MDA, caspase-3, and PCNA of the prostate were determined. Animals with BPH demonstrated significantly increased prostate weights and prostate index, higher levels of IL-8, TNF-, DHT, MDA, and PCNA, but lower activity of SOD and reduced expression of caspase-3. After treatment with , significant reductions of prostate weights, prostate index, IL-8, TNF-, DHT, MDA, and PCNA, increased activity of SOD, and higher level of caspase-3 were shown. The present study indicates that can effectively prevent the development of TP-induced BPH model through mechanisms of anti-inflammation, antioxidation, antiproliferation, and proapoptosis.
良性前列腺增生（BPH）在老年男性中很常见，其中炎症、氧化应激、增殖和凋亡变化起着重要作用。（）胶囊，一种传统的中药配方，被用作治疗BPH的潜在药物。本研究旨在评估（）胶囊对丙酸睾酮（TP）诱导的大鼠BPH的治疗效果。50只雄性Sprague-Dawley大鼠随机分为5组：假手术对照组、BPH模型组、高剂量和低剂量（）组以及非那雄胺作为阳性对照组。所有组连续28天用适当的药物/生理盐水治疗。记录前列腺重量；测定前列腺的组织病理学变化以及IL-8、TNF-、双氢睾酮（DHT）、超氧化物歧化酶（SOD）、丙二醛（MDA）、半胱天冬酶-3（caspase-3）和增殖细胞核抗原（PCNA）的含量。患有BPH的动物前列腺重量和前列腺指数显著增加，IL-8、TNF-、DHT、MDA和PCNA水平升高，但SOD活性降低且caspase-3表达减少。用（）治疗后，前列腺重量、前列腺指数、IL-8、TNF-、DHT、MDA和PCNA显著降低，SOD活性增加，caspase-3水平升高。本研究表明，（）可通过抗炎、抗氧化、抗增殖和促凋亡机制有效预防TP诱导的BPH模型的发展。
