Urizar R E, Singh J K, Muhammad T, Hines O
Hum Pathol. 1978 Mar;9(2):223-9. doi: 10.1016/s0046-8177(78)80113-0.
The clinical, laboratory, and histologic features of a patient with Henoch-Schönlein syndrome are presented. The skin biopsy examination showed "leucocytoclastic vasculitis." Kidney tissue demonstrated deposits of IgG, C3, and fibrinogenfibrin by fluorescence microscopy in the mesangium and the peripheral glomerular basement membrane in a granular-nodular pattern. These correlated well with areas of mesangial hyperplasia and polymorphonuclear leucocyte infiltration seen by light and electron microscopy. Several well delineated, variably sized, subepithelial electron dense deposits flanked by polymorphonuclear leucotytes adherent to the glomerular basement membrane were seen in two of the four glomeruli examined by electron microscopy. The significance of these findings is discussed. A detailed ultrastructural evaluation of patients with Henoch-Schönlein nephropathy may yield information about the frequency of subepithelial deposits and perhaps may help to clarify the pathogenesis of this syndrome.
本文介绍了一名过敏性紫癜患者的临床、实验室及组织学特征。皮肤活检显示“白细胞破碎性血管炎”。肾脏组织经荧光显微镜检查显示，免疫球蛋白G、补体C3及纤维蛋白原-纤维蛋白在系膜及外周肾小球基底膜呈颗粒状-结节状沉积。这些与光镜及电镜下所见的系膜增生及多形核白细胞浸润区域密切相关。在接受电镜检查的四个肾小球中的两个中，可见有多个界限清楚、大小不一的上皮下电子致密沉积物，周围有多形核白细胞附着于肾小球基底膜。文中讨论了这些发现的意义。对过敏性紫癜性肾病患者进行详细的超微结构评估，可能会获得有关上皮下沉积物频率的信息，或许有助于阐明该综合征的发病机制。
