Department of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Paediatrics, Halland Hospital Halmstad, Halmstad, Sweden.
Acta Paediatr. 2022 Feb;111(2):338-345. doi: 10.1111/apa.16151. Epub 2021 Nov 11.
The hormone osteocalcin influenced neurodevelopment and cognition in mice models; this human study explored potential associations between total serum levels in human infants and neurodevelopment at 4 years of age.
The data were based on two Swedish birth cohorts from 2008 to 2009. We followed 158 healthy full-term vaginal births (51% girls) by measuring serum osteocalcin in cord blood and at 4, 12 and 36 months. The values were compared with neurodevelopment tests at 4 years of age.
There was an association between osteocalcin at 4 months and later full-scale intelligence quotient (IQ; r 0.031, p < 0.05). Children with osteocalcin levels in the highest quartile scored 5.6 (95% confidence interval [1.3, 9.9]) points higher than those in the lowest quartile, with mean scores of 118.8 ± 8.8 and 113.2 ± 9.2 (p < 0.05). They also scored higher on gross motor skills (p < 0.05) and showed greater ability during the drawing trail test (p < 0.005). Cord levels of osteocalcin were negatively associated with processing speed and fine motor development at 4 years, but levels at 12 and 36 months were not associated with later neurodevelopment.
Osteocalcin levels in infancy appeared to be associated with later IQ and motor development, but more research is needed.
骨钙素会影响小鼠模型的神经发育和认知；本项人类研究旨在探索人类婴儿血清总水平与 4 岁时神经发育之间的潜在关联。
该数据基于 2008 年至 2009 年的两项瑞典出生队列研究。我们通过测量脐带血和 4、12 和 36 个月时的血清骨钙素来随访 158 例健康足月阴道分娩（51%为女孩）的婴儿。将这些值与 4 岁时的神经发育测试进行比较。
4 个月时的骨钙素与之后的总智商（IQ）呈正相关（r=0.031，p<0.05）。骨钙素水平处于最高四分位数的儿童比处于最低四分位数的儿童的智商高出 5.6 分（95%置信区间[1.3，9.9]），平均得分分别为 118.8±8.8 和 113.2±9.2（p<0.05）。他们在粗大运动技能方面的得分也更高（p<0.05），在绘图轨迹测试中表现出更强的能力（p<0.005）。脐带血中的骨钙素水平与 4 岁时的处理速度和精细运动发育呈负相关，但 12 个月和 36 个月时的水平与之后的神经发育无关。
婴儿期的骨钙素水平似乎与之后的智商和运动发育有关，但需要进一步研究。
