从. 的种皮中分离得到一个新的贝壳杉烷二萜。
A new ent-kaurane diterpenoid from the pericarps of .
机构信息
Key Laboratory of Chinese Materia Medica, Ministry of Education, Faculty of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Guizhou University of Traditional Chinese Medicine, Guizhou 550025, China.
出版信息
J Asian Nat Prod Res. 2022 Sep;24(9):884-890. doi: 10.1080/10286020.2021.1981874. Epub 2021 Oct 14.
A new ent-kaurane diterpenoid, named kaurane daturoside A (), was isolated from the 70%-EtOH extract of dried pericarps of L., along with six known terpenoids, 16,17-dihydroxy-ent-kauran-19-diglycoside (), cyclosieversioside F (), astragaloside II (), ginsenoside Rg1 (), astrojanoside A (), celerioside E (). The isolated structures were elucidated by means of spectroscopic analyses, and the compounds , , were separated from Solanaceae for the first time. Meanwhile, among isolates, compounds and exhibited anti-inflammatory activities against LPS-activated RAW264.7 cells (IC<11.00 M).
从 L. 的干燥种皮的 70%-EtOH 提取物中分离得到一种新的-ent-贝壳杉烷二萜，命名为贝壳杉烷 daturoside A ()，此外还分离得到了 6 种已知萜类化合物，16,17-二羟基-ent-贝壳杉-19-二糖苷 ()、环塞维罗斯苷 F ()、黄芪苷 II ()、人参皂苷 Rg1 ()、阿斯特拉苷 A ()和芹菜苷 E ()。通过光谱分析阐明了分离结构，化合物 、 、 首次从茄科植物中分离得到。同时，在所分离的化合物中，化合物 和 对 LPS 激活的 RAW264.7 细胞表现出抗炎活性（IC<11.00 M）。
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