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[前庭代偿与衰老:细胞和行为随时间的恢复力实例]

[Vestibular compensation and aging: An example of cellular and behavioral resilience over time].

作者信息

Tighilet Brahim

机构信息

Aix Marseille Université-CNRS UMR 7291, laboratoire de neurosciences cognitives, équipe physiopathologie et thérapie des désordres vestibulaires, groupe de recherche Vertige (GDR#2074), 3 place Victor Hugo, 13000 Marseille, France.

出版信息

Med Sci (Paris). 2021 Oct;37(10):851-862. doi: 10.1051/medsci/2021144. Epub 2021 Oct 14.

Abstract

The vestibular system has a remarkable capacity of self-repair. Vestibular compensation, a model of post-lesional plasticity of the central nervous system, refers to a set of endogenous neuroplasticity mechanisms in the vestibular nuclei in response to damage to the peripheral vestibular system, and underlying functional recovery. During aging, this "homeostatic" plasticity, although still present, diminishes and is accompanied by sensorimotor and cognitive disturbances. Regardless of age, vestibular compensation can be improved by pharmacological therapy but also by rehabilitation based on strengthening other sensory modalities such as visual and proprioceptive modalities, but also cognitive and motor components. In this article, we will first discuss neurobiological mechanisms of vestibular compensation, then document the impact of aging on this adaptive plasticity.

摘要

前庭系统具有显著的自我修复能力。前庭代偿是中枢神经系统损伤后可塑性的一种模式,指的是前庭核内的一组内源性神经可塑性机制,以应对外周前庭系统损伤并实现潜在的功能恢复。在衰老过程中,这种“稳态”可塑性虽然仍然存在,但会减弱,并伴有感觉运动和认知障碍。无论年龄大小,前庭代偿都可以通过药物治疗得到改善,也可以通过基于强化其他感觉模式(如视觉和本体感觉模式)以及认知和运动成分的康复来改善。在本文中,我们将首先讨论前庭代偿的神经生物学机制,然后阐述衰老对这种适应性可塑性的影响。

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