David Arthur, Chaker Jade, Multigner Luc, Bessonneau Vincent
Univ Rennes, Inserm, École des hautes études en santé publique (EHESP), Institut de recherche en santé, environnement et travail (Irset) - UMR_S 1085, 15 avenue du Professeur Léon Bernard, 35043 Rennes, France.
Med Sci (Paris). 2021 Oct;37(10):895-901. doi: 10.1051/medsci/2021088. Epub 2021 Oct 14.
The technological advances in high-resolution mass spectrometry (HRMS), associated with the development of bioinformatics tools, allows the simultaneous detection of tens of thousands of chemical signals in biological matrices, including exogenous (i.e. xenobiotics) and endogenous molecules. These novel approaches based on HRMS, called "non-targeted" approaches, provide a unique opportunity to capture exposures to a wide range of chemicals (i.e. the internal chemical exposome) in populations, and to better understand the links between chemical exposures and the occurrence of chronic diseases.
高分辨率质谱（HRMS）技术的进步，与生物信息学工具的发展相结合，使得能够同时检测生物基质中的数万个化学信号，包括外源性（即异种生物）和内源性分子。这些基于HRMS的新方法，即“非靶向”方法，为了解人群中广泛的化学物质暴露情况（即内部化学暴露组）以及更好地理解化学物质暴露与慢性病发生之间的联系提供了独特的机会。
