• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
A 646C > G (rs41423247) polymorphism of the glucocorticoid receptor as a risk factor for hyperglycaemia diagnosed in pregnancy-data from an observational study.糖皮质激素受体 646C > G（rs41423247）多态性与妊娠期间诊断的高血糖风险相关：一项观察性研究的数据。
Acta Diabetol. 2022 Feb;59(2):259-267. doi: 10.1007/s00592-021-01799-3. Epub 2021 Oct 14.
2
Glucocorticoid Receptor Genetic Variants and Response to Fluoxetine in Major Depressive Disorder.糖皮质激素受体基因变异与重度抑郁症患者对氟西汀的反应
J Neuropsychiatry Clin Neurosci. 2018 Winter;30(1):45-50. doi: 10.1176/appi.neuropsych.16120322. Epub 2017 Jun 23.
3
Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior.rs41423247 处糖皮质激素受体基因的变异调节产前母亲心理症状对儿童皮质醇反应性和行为的影响。
Neuropsychopharmacology. 2012 Oct;37(11):2541-9. doi: 10.1038/npp.2012.118. Epub 2012 Jul 11.
4
Genetic Variant of Glucocorticoid Receptor Gene at rs41423247 and Its Association with Major Depressive Disorder: A Case-Control Study.糖皮质激素受体基因rs41423247的基因变异及其与重度抑郁症的关联：一项病例对照研究。
Galen Med J. 2018 Dec 31;7:e1181. doi: 10.22086/gmj.v0i0.1181. eCollection 2018.
5
Dual biomarkers long non-coding RNA GAS5 and its target, NR3C1, contribute to acute myeloid leukemia.双重生物标志物长非编码 RNA GAS5 及其靶基因 NR3C1 促进急性髓系白血病的发生。
Exp Mol Pathol. 2020 Jun;114:104399. doi: 10.1016/j.yexmp.2020.104399. Epub 2020 Feb 4.
6
Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritis.糖皮质激素受体基因和糖皮质激素诱导转录物1基因的多态性与类风湿关节炎的疾病活动及对糖皮质激素桥接治疗的反应相关。
Rheumatol Int. 2015 Aug;35(8):1325-33. doi: 10.1007/s00296-015-3235-z. Epub 2015 Feb 28.
7
Glucocorticoid Receptor Gene Variants and Neonatal Outcome in Very-Low-Birth-Weight Preterm Infants.极低出生体重早产儿的糖皮质激素受体基因变异与新生儿结局
Neonatology. 2017;111(1):22-29. doi: 10.1159/000446908. Epub 2016 Aug 11.
8
Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men.糖皮质激素受体基因多态性与女性的第一时相葡萄糖刺激胰岛素分泌和处置指数降低有关，但与男性无关。
Diabet Med. 2012 Aug;29(8):e211-6. doi: 10.1111/j.1464-5491.2012.03690.x.
9
Glucocorticoid Receptor Polymorphisms and Avascular Osteonecrosis After Kidney Transplantation.糖皮质激素受体多态性与肾移植后缺血性骨坏死。
Iran J Kidney Dis. 2023 Mar;1(2):86-91.
10
NR3C1 polymorphisms in Brazilians of Caucasian, African, and Asian ancestry: glucocorticoid sensitivity and genotype association.具有高加索、非洲和亚洲血统的巴西人的NR3C1基因多态性：糖皮质激素敏感性与基因型关联
Arq Bras Endocrinol Metabol. 2014 Feb;58(1):53-61. doi: 10.1590/0004-2730000002868.

引用本文的文献

1
[Association of the structure of the glucocorticoid receptor and single nucleotide gene polymorphisms with metabolic disorders].[糖皮质激素受体结构与单核苷酸基因多态性与代谢紊乱的关联]
Probl Endokrinol (Mosk). 2023 Feb 25;69(1):50-58. doi: 10.14341/probl13160.
2
Familial Linkage and Association of the Gene with Type 2 Diabetes and Depression Comorbidity.家族连锁与 2 型糖尿病和抑郁症共病的 基因关联。
Int J Mol Sci. 2022 Oct 8;23(19):11951. doi: 10.3390/ijms231911951.

本文引用的文献

1
The Impact of Diagnostic Criteria for Gestational Diabetes Mellitus on Adverse Maternal Outcomes: A Systematic Review and Meta-Analysis.妊娠期糖尿病诊断标准对孕产妇不良结局的影响：一项系统评价和荟萃分析
J Clin Med. 2021 Feb 9;10(4):666. doi: 10.3390/jcm10040666.
2
Impact of maternal prenatal stress by glucocorticoids on metabolic and cardiovascular outcomes in their offspring: A systematic scoping review.母体产前应激激素皮质醇对子代代谢和心血管结局的影响：系统范围综述。
PLoS One. 2021 Jan 22;16(1):e0245386. doi: 10.1371/journal.pone.0245386. eCollection 2021.
3
Prospective associations between maternal stress during pregnancy and fasting glucose with obstetric and neonatal outcomes.孕期母亲压力与空腹血糖与产科及新生儿结局的前瞻性关联。
J Psychosom Res. 2019 Oct;125:109795. doi: 10.1016/j.jpsychores.2019.109795. Epub 2019 Aug 6.
4
Prioritising Causal Genes at Type 2 Diabetes Risk Loci.对2型糖尿病风险位点的因果基因进行优先级排序。
Curr Diab Rep. 2017 Sep;17(9):76. doi: 10.1007/s11892-017-0907-y.
5
Healthy glucocorticoid receptor N363S carriers dysregulate gene expression associated with metabolic syndrome.健康的糖皮质激素受体N363S携带者会使与代谢综合征相关的基因表达失调。
Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E741-E748. doi: 10.1152/ajpendo.00105.2016. Epub 2016 Sep 6.
6
The Diabetes Risk Phenotype of Young Women With Recent Gestational Diabetes.近期患有妊娠期糖尿病的年轻女性的糖尿病风险表型
J Clin Endocrinol Metab. 2015 Jun;100(6):E910-8. doi: 10.1210/jc.2014-3898. Epub 2015 Mar 5.
7
Mechanisms linking in utero stress to altered offspring behaviour.将子宫内应激与后代行为改变相联系的机制。
Curr Top Behav Neurosci. 2014;18:93-122. doi: 10.1007/7854_2014_291.
8
Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring.孕期母体暴露于社会压力的影响：对母婴的后果。
Reproduction. 2013 Oct 1;146(5):R175-89. doi: 10.1530/REP-13-0258. Print 2013.
9
Risk factors for type 2 diabetes among women with gestational diabetes: a systematic review.妊娠糖尿病女性患2型糖尿病的风险因素：一项系统综述。
Am J Med. 2009 Mar;122(3):207-214.e4. doi: 10.1016/j.amjmed.2008.09.034.
10
Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.常见糖皮质激素受体基因变异与下丘脑-垂体-肾上腺轴对心理社会应激反应之间的性别特异性关联。
Biol Psychiatry. 2007 Oct 15;62(8):863-9. doi: 10.1016/j.biopsych.2007.04.013. Epub 2007 Aug 23.

糖皮质激素受体 646C > G（rs41423247）多态性与妊娠期间诊断的高血糖风险相关：一项观察性研究的数据。

A 646C > G (rs41423247) polymorphism of the glucocorticoid receptor as a risk factor for hyperglycaemia diagnosed in pregnancy-data from an observational study.

机构信息

Chair of Medical Education, Department of Medical Simulation, Poznan University of Medical Sciences, Poznan, Poland.

Institute of Natural Fibers and Medicinal Plants, National Research Institute, Poznan, Poland.

出版信息

Acta Diabetol. 2022 Feb;59(2):259-267. doi: 10.1007/s00592-021-01799-3. Epub 2021 Oct 14.

DOI:10.1007/s00592-021-01799-3
PMID:34648084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8841327/
Abstract

AIM

Hyperglycaemia diagnosed in pregnancy (HiP) is a serious and frequent complication of pregnancy, increasing the risk for adverse maternal and neonatal outcomes. Investigate whether allelic variations of the glucocorticoid receptor are related to an increased risk of HiP.

METHOD

The following polymorphisms of the glucocorticoid receptor (GR) were investigated in the cohort study of N = 197 pregnant women with HiP and N = 133 normoglycemic pregnant controls: 646C > G (rs41423247), N363S (rs6195), ER23/22EK (rs6190, rs6189).

RESULTS

A GG variant of the rs41423247 polymorphism was associated with a significantly higher risk for HiP: OR 1.94 (1.18; 3.18), p = 0.009. The relationship remained significant after controlling for maternal age and prepregnancy BMI: OR 3.09 (1.25; 7.64), p = 0.014.

CONCLUSIONS

The allelic GG variant of the 646C > G (rs41423247) polymorphism is associated with an increased risk for hyperglycaemia in pregnancy.

摘要

目的

妊娠期间诊断的高血糖症（HiP）是一种严重且常见的妊娠并发症，增加了不良母婴结局的风险。研究糖皮质激素受体的等位基因变异是否与 HiP 的风险增加有关。

方法

在一项 197 例 HiP 孕妇和 133 例血糖正常孕妇的队列研究中，研究了糖皮质激素受体（GR）的以下多态性：646C>G（rs41423247）、N363S（rs6195）、ER23/22EK（rs6190、rs6189）。

结果

rs41423247 多态性的 GG 变异与 HiP 的风险显著增加相关：OR 1.94（1.18；3.18），p=0.009。在控制了母亲年龄和孕前 BMI 后，这种关系仍然显著：OR 3.09（1.25；7.64），p=0.014。

结论

646C>G（rs41423247）多态性的等位基因 GG 变异与妊娠期间高血糖症的风险增加相关。