Chair of Medical Education, Department of Medical Simulation, Poznan University of Medical Sciences, Poznan, Poland.
Institute of Natural Fibers and Medicinal Plants, National Research Institute, Poznan, Poland.
Acta Diabetol. 2022 Feb;59(2):259-267. doi: 10.1007/s00592-021-01799-3. Epub 2021 Oct 14.
Hyperglycaemia diagnosed in pregnancy (HiP) is a serious and frequent complication of pregnancy, increasing the risk for adverse maternal and neonatal outcomes. Investigate whether allelic variations of the glucocorticoid receptor are related to an increased risk of HiP.
The following polymorphisms of the glucocorticoid receptor (GR) were investigated in the cohort study of N = 197 pregnant women with HiP and N = 133 normoglycemic pregnant controls: 646C > G (rs41423247), N363S (rs6195), ER23/22EK (rs6190, rs6189).
A GG variant of the rs41423247 polymorphism was associated with a significantly higher risk for HiP: OR 1.94 (1.18; 3.18), p = 0.009. The relationship remained significant after controlling for maternal age and prepregnancy BMI: OR 3.09 (1.25; 7.64), p = 0.014.
The allelic GG variant of the 646C > G (rs41423247) polymorphism is associated with an increased risk for hyperglycaemia in pregnancy.
妊娠期间诊断的高血糖症（HiP）是一种严重且常见的妊娠并发症，增加了不良母婴结局的风险。研究糖皮质激素受体的等位基因变异是否与 HiP 的风险增加有关。
在一项 197 例 HiP 孕妇和 133 例血糖正常孕妇的队列研究中，研究了糖皮质激素受体（GR）的以下多态性：646C>G（rs41423247）、N363S（rs6195）、ER23/22EK（rs6190、rs6189）。
rs41423247 多态性的 GG 变异与 HiP 的风险显著增加相关：OR 1.94（1.18；3.18），p=0.009。在控制了母亲年龄和孕前 BMI 后，这种关系仍然显著：OR 3.09（1.25；7.64），p=0.014。
646C>G（rs41423247）多态性的等位基因 GG 变异与妊娠期间高血糖症的风险增加相关。
