Kidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Iran J Kidney Dis. 2023 Mar;1(2):86-91.
Glucocorticoids (GCs) are commonly prescribed as immunosuppressive agents after kidney transplantation and their most common non-traumatic adverse effect is Avascular Necrosis (AVN) of the femoral head. In this regard, this study aimed to evaluate the glucocorticoid receptor (GR) polymorphisms among kidney transplant recipients and their potential role as a risk factor for the incidence of AVN.
In this study, 99 renal transplant recipients were evaluated for the correlations of GR polymorphisms including N363S (rs6195), BclI (rs41423247), ER22/23EK (rs6189/rs6190), and A3669G (rs6198) with AVN after renal transplantation.
Results showed that none of the renal-transplanted patients neither with GC hypersensitive polymorphisms (N363S and BclI) nor with GC-resistant polymorphisms (A3669G and ER22/23EK) developed AVN (P > .05). In addition, the medications of the renal recipients with AVN were significantly different from the nonAVN patients (P < .001).
The study results indicate that the GR polymorphisms have no critical roles in the susceptibility to AVN after renal transplantation. However, further studies to confirm the results are recommended. DOI: 10.52547/ijkd.7221.
糖皮质激素（GCs）在肾移植后常被用作免疫抑制剂，其最常见的非创伤性不良反应是股骨头缺血性坏死（AVN）。在这方面，本研究旨在评估肾移植受者中糖皮质激素受体（GR）多态性及其作为 AVN 发生率的危险因素的潜在作用。
在这项研究中，评估了 99 例肾移植受者的 GR 多态性与肾移植后 AVN 的相关性，包括 N363S（rs6195）、BclI（rs41423247）、ER22/23EK（rs6189/rs6190）和 A3669G（rs6198）。
结果显示，既没有 GC 高敏多态性（N363S 和 BclI）也没有 GC 耐药多态性（A3669G 和 ER22/23EK）的肾移植患者均未发生 AVN（P >.05）。此外，发生 AVN 的肾移植受者的用药与非 AVN 患者明显不同（P <.001）。
研究结果表明，GR 多态性在肾移植后发生 AVN 中的作用不具有关键意义。然而，建议进一步研究以确认结果。DOI：10.52547/ijkd.7221.
