评论“古皮质类器官中 的古老变体的再引入改变了神经发育”。
Comment on "Reintroduction of the archaic variant of in cortical organoids alters neurodevelopment".
机构信息
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Okinawa Institute of Science and Technology, Onna-son, Okinawa 904-0495, Japan.
出版信息
Science. 2021 Oct 15;374(6565):eabi6060. doi: 10.1126/science.abi6060. Epub 2021 Oct 14.
Trujillo . (Research Articles, 12 February 2021, eaax2537) conclude that the reintroduction of an ancestral amino acid substitution in the protein NOVA1 drastically alters the development of brain organoids. We show that cell lines used by the authors carry heterozygous deletions of the target DNA sequence, providing another plausible explanation for the effects observed.
特鲁希略等人（研究文章，2021 年 2 月 12 日，eaax2537）得出结论，蛋白质 NOVA1 中引入一个祖先氨基酸取代会极大地改变脑类器官的发育。我们发现，作者所用的细胞系携带目标 DNA 序列的杂合性缺失，这为观察到的效应提供了另一种合理的解释。
Zotero 插件