对“在皮质类器官中引入古老的变体 会改变神经发育”一文的评论的回复。
Response to Comment on "Reintroduction of the archaic variant of in cortical organoids alters neurodevelopment".
机构信息
Experimental Multiuser Laboratory (LEM), Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil.
Department of Pediatrics and Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
出版信息
Science. 2021 Oct 15;374(6565):eabi9881. doi: 10.1126/science.abi9881. Epub 2021 Oct 14.
Maricic . performed an undisclosed in silico–only whole-exome sequencing analysis of our data and found genomic alterations previously undetected in some clones. Some of the predicted alterations, if true, could change the original genotype of the clones. We failed to experimentally validate all but one of these genomic alterations, which did not affect our previous results or data interpretation.
马里奇. 对我们的数据进行了一次未公开的仅基于计算机的全外显子组测序分析，发现了一些以前在某些克隆中未检测到的基因组改变。如果这些预测的改变是真实的，可能会改变克隆的原始基因型。我们未能对所有这些基因组改变进行实验验证，其中只有一个改变不影响我们之前的结果或数据解释。
Zotero 插件