RNA 甲基化与癌症治疗。
RNA methylation and cancer treatment.
机构信息
Department of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, PR China; University of Science and Technology, Shenzhen, Guangdong, PR China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, Guangdong, PR China.
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, New York, USA.
出版信息
Pharmacol Res. 2021 Dec;174:105937. doi: 10.1016/j.phrs.2021.105937. Epub 2021 Oct 12.
To this date, over 100 different types of RNA modification have been identified. Methylation of different RNA species has emerged as a critical regulator of transcript expression. RNA methylation and its related downstream signaling pathways are involved in plethora biological processes, including cell differentiation, sex determination and stress response, and others. It is catalyzed by the RNA methyltransferases, is demethylated by the demethylases (FTO and ALKBH5) and read by methylation binding protein (YTHDF1 and IGF2BP1). Increasing evidence indicates that this process closely connected to cancer cell proliferation, cellular stress, metastasis, immune response. And RNA methylation related protein has been becoming a promising targets of cancer therapy. This review outlines the relationship between different types of RNA methylation and cancer, and some FTO inhibitors in cancer treatment.
迄今为止，已经鉴定出超过 100 种不同类型的 RNA 修饰。不同 RNA 种类的甲基化已成为转录表达的关键调节剂。RNA 甲基化及其相关下游信号通路参与了丰富的生物学过程，包括细胞分化、性别决定和应激反应等。它由 RNA 甲基转移酶催化，由去甲基酶（FTO 和 ALKBH5）去甲基化，并由甲基化结合蛋白（YTHDF1 和 IGF2BP1）读取。越来越多的证据表明，这一过程与癌细胞增殖、细胞应激、转移、免疫反应密切相关。RNA 甲基化相关蛋白已成为癌症治疗的有前途的靶点。本综述概述了不同类型的 RNA 甲基化与癌症的关系，以及一些 FTO 抑制剂在癌症治疗中的应用。
Zotero 插件