两例 COVID-19 疫苗接种后出现面瘫的吉兰-巴雷综合征。
Guillain-Barré syndrome presenting with facial diplegia following COVID-19 vaccination in two patients.
机构信息
Department of Clinical Neurophysiology, East and North Hertfordshire NHS Trust, Stevenage, UK
Department of Clinical Neurophysiology, Great Ormond Street Hospital for Children, London, UK.
出版信息
BMJ Case Rep. 2021 Oct 14;14(10):e244527. doi: 10.1136/bcr-2021-244527.
In March 2020, the WHO declared COVID-19 to be a global pandemic and since December 2020, millions of vaccines have been administered. To date, cases of Guillain-Barré syndrome (GBS) following a COVID vaccine (Pfizer, Johnson & Johnson, Janssen, AstraZeneca) have been reported. A 61-year-old woman developed bilateral asymmetrical lower motor neuron (LMN) facial weakness followed by limb symptoms, 10 days after receiving the first dose of AstraZeneca COVID vaccine. The second patient was a 56-year-old man who, 9 days after receiving first dose of AstraZeneca COVID vaccine, developed bilateral asymmetrical LMN facial weakness with limb symptoms. Intravenous immunoglobulin was administered with rapid recovery. These cases of GBS following the AstraZeneca COVID vaccine add to cohort of patients reported. We flag up to raise awareness of this condition post-COVID-19 vaccine and highlight the prominent bifacial involvement. Early diagnosis and prompt treatment with intravenous immunoglobulin led to rapid recovery.
2020 年 3 月，世界卫生组织宣布 COVID-19 为全球大流行疾病，自 2020 年 12 月以来，已经接种了数百万支疫苗。迄今为止，已经报告了在接种 COVID 疫苗（辉瑞、强生、杨森、阿斯利康）后出现吉兰-巴雷综合征（GBS）的病例。一名 61 岁女性在接种阿斯利康 COVID 疫苗第一剂后 10 天出现双侧非对称下运动神经元（LMN）面部无力，随后出现四肢症状。第二例患者为 56 岁男性，在接种阿斯利康 COVID 疫苗第一剂后 9 天出现双侧非对称 LMN 面部无力伴四肢症状。给予静脉注射免疫球蛋白后迅速恢复。这些阿斯利康 COVID 疫苗接种后的 GBS 病例增加了报告的患者队列。我们提出这一情况，以提高人们对 COVID-19 疫苗接种后这种疾病的认识，并强调突出的两面性受累。早期诊断和及时使用静脉注射免疫球蛋白治疗可迅速恢复。
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