Department of Neurology, District Hospital Pardubice, Czech Republic.
Department of Radiology, Faculty of Health-Care study, Pardubice University, District Hospital Pardubice, Czech Republic.
Acta Medica (Hradec Kralove). 2021;64(3):183-186. doi: 10.14712/18059694.2021.31.
A number of neurological complications have been reported after the administration of flu vaccine, including Guillain-Barré syndrome (GBS), especially after vaccination against swine flu. Only facial nerve neuropathy has thus far been reported after vaccination against COVID-19. More recently, there was a case of an elderly woman with GBS. In our report, we describe a case of a 42-year-old, previously almost healthy male who developed sensory symptoms 14 days after the first dose of Pfizer vaccine. One week later, the patient developed right facial nerve palsy and lower limb weakness and was no longer able to walk. Albuminocytological dissociation was detected in the cerebrospinal fluid, and there were inflammatory radicular changes in MRI scans of the lumbosacral spine. EMG indicated significant demyelinating polyradiculoneuritis and no antibodies against gangliosides were demonstrated. A 5-day course of immunoglobulins at a dose of 2 g/kg lead to a significant improvement and the patient was soon able to walk. In conclusion, we report a case of Guillan-Barré syndrome after COVID-19 vaccine in a young patient with a rapid diagnosis and prompt administration of immunoglobulins.
接种流感疫苗后，已报告了许多神经并发症，包括格林-巴利综合征（GBS），尤其是在接种猪流感疫苗后。迄今为止，仅在接种 COVID-19 疫苗后报告了面神经神经病。最近，有一例老年妇女发生 GBS。在我们的报告中，我们描述了一例 42 岁的几乎健康的男性患者，在接受第一剂辉瑞疫苗后 14 天出现感觉症状。一周后，患者出现右侧面神经瘫痪和下肢无力，无法行走。脑脊液中检测到白蛋白细胞分离，腰骶部 MRI 扫描显示炎症性神经根改变。EMG 提示明显的脱髓鞘性多神经根炎，未检测到神经节苷脂抗体。5 天 2g/kg 的免疫球蛋白治疗后，病情显著改善，患者很快就能行走。总之，我们报告了一例年轻患者接种 COVID-19 疫苗后发生格林-巴利综合征，该患者诊断迅速，及时给予免疫球蛋白治疗。
