Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Aichi, 464-8550, Japan.
Takayama City Hall Public Health Department, Takayama, Gifu, Japan.
Sci Rep. 2021 Oct 14;11(1):20440. doi: 10.1038/s41598-021-99222-y.
The influence of body mass or metabolic capacity on the association between alcohol consumption and lower risks of developing chronic kidney disease (CKD) is not fully elucidated. We examined whether the body mass index (BMI) affects the association between drinking alcohol and CKD. We defined CKD as an estimated glomerular filtration rate decline < 60 mL/min/1.73 m and/or positive proteinuria (≥ 1+). Participants were 11,175 Japanese individuals aged 40-74 years without baseline CKD who underwent annual health checkups. Daily alcohol consumption at baseline was estimated using a questionnaire, and the participants were categorized as "infrequent (occasionally, rarely or never)," "light (< 20 g/day)," "moderate (20-39 g/day)," and "heavy (≥ 40 g/day)." Over a median 5-year observation period, 936 participants developed CKD. Compared with infrequent drinkers, light drinkers were associated with low CKD risks; adjusted hazard ratios (95% confidence intervals) were 0.81 (0.69-0.95). Stratified by BMI (kg/m), moderate drinkers in the low (< 18.5), normal (18.5-24.9), and high (≥ 25.0) BMI groups had adjusted hazard ratios (95% confidence intervals) of 3.44 (1.60-7.42), 0.75 (0.58-0.98), and 0.63 (0.39-1.04), respectively. Taken together, the association between alcohol consumption and CKD incidence was not the same in all the individuals, and individual tolerance must be considered.
体重或代谢能力对饮酒与慢性肾脏病（CKD）风险降低之间关联的影响尚未完全阐明。我们研究了体重指数（BMI）是否会影响饮酒与 CKD 之间的关联。我们将 CKD 定义为估算肾小球滤过率下降<60ml/min/1.73m2 和/或蛋白尿阳性（≥1+）。参与者为 11175 名年龄在 40-74 岁之间、基线时无 CKD 的日本个体，他们接受了年度健康检查。使用问卷估计基线时的每日饮酒量，参与者被分为“不常饮酒（偶尔、很少或从不饮酒）”、“轻度饮酒（<20g/天）”、“中度饮酒（20-39g/天）”和“重度饮酒（≥40g/天）”。在中位 5 年的观察期内，936 名参与者发展为 CKD。与不常饮酒者相比，轻度饮酒者发生 CKD 的风险较低；调整后的危险比（95%置信区间）为 0.81（0.69-0.95）。按 BMI（kg/m2）分层，低（<18.5）、正常（18.5-24.9）和高（≥25.0）BMI 组中的中度饮酒者调整后的危险比（95%置信区间）分别为 3.44（1.60-7.42）、0.75（0.58-0.98）和 0.63（0.39-1.04）。总之，饮酒与 CKD 发病率之间的关联在所有个体中并不相同，必须考虑个体的耐受性。
