Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Genetics, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nat Hum Behav. 2020 Mar;4(3):308-316. doi: 10.1038/s41562-019-0805-1. Epub 2020 Jan 20.
Dietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human diseases. We performed genome-wide association studies for 13 dietary habits including consumption of alcohol (ever versus never drinkers and drinks per week), beverages (coffee, green tea and milk) and foods (yoghurt, cheese, natto, tofu, fish, small whole fish, vegetables and meat) in Japanese individuals (n = 58,610-165,084) collected by BioBank Japan, the nationwide hospital-based genome cohort. Significant associations were found in nine genetic loci (MCL1-ENSA, GCKR, AGR3-AHR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, CYP1A2-CSK and ADORA2A-AS1) for 13 dietary traits (P < 3.8 × 10). Of these, ten associations between five loci and eight traits were new findings. Furthermore, a phenome-wide association study revealed that five of the dietary trait-associated loci have pleiotropic effects on multiple human complex diseases and clinical measurements. Our findings provide new insight into the genetics of habitual consumption.
饮食习惯是我们生活方式中的重要因素，它们既会影响我们易患某些疾病的倾向，也会影响我们对这些疾病的保护作用。我们对日本生物银行（BioBank Japan）中收集的 58610 至 165084 名个体的 13 种饮食习惯（包括饮酒（是否饮酒以及每周饮酒量）、饮料（咖啡、绿茶和牛奶）和食物（酸奶、奶酪、纳豆、豆腐、鱼、小鱼、蔬菜和肉）进行了全基因组关联研究。在 13 种饮食特征（MCL1-ENSA、GCKR、AGR3-AHR、ADH1B、ALDH1B1、ALDH1A1、ALDH2、CYP1A2-CSK 和 ADORA2A-AS1）的 9 个遗传位点发现了显著关联（P < 3.8×10）。其中，5 个位点与 8 个特征之间的 10 个关联是新发现的。此外，表型全基因组关联研究表明，与 8 个饮食特征相关的 5 个位点对多种人类复杂疾病和临床测量指标具有多效性影响。我们的研究结果为习惯性消费的遗传学提供了新的见解。
