氟伐他汀联合虫草胶囊在慢性阻塞性肺疾病治疗中可改善抑郁和焦虑症状。
Fluvastatin combined with corbrin capsule can improve depression and anxiety in the treatment of chronic obstructive pulmonary disease.
作者信息
Zhu Jia, Yan Lei, Ji Jia-Ni, Chen Fei, Mei Li-Ban, Cheng Na, Shan Zi-Mei, Wang Jian-Bin
机构信息
The Third Ward of Cadre Health Center, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
Department of Anesthesiology, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
出版信息
Am J Transl Res. 2021 Sep 15;13(9):10501-10508. eCollection 2021.
OBJECTIVE
To investigate the effect of fluvastatin (Flu) combined with corbrin capsule (CC) on the pulmonary function (PF) in patients with chronic obstructive pulmonary disease (COPD).
METHODS
Totally, 156 patients with COPD treated in our hospital were assigned: 86 patients in the research group (RG), who were treated with Flu plus CC, and 70 patients in the control group (CG), who were treated with CC plus conventional drugs. The changes in inflammatory factors, including interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and procalcitonin (PCT), of the two groups before and after treatment were compared. The complications, psychological status, quality of life (QOL) and recurrence rate of the two groups were analyzed.
RESULTS
The total effective rate in the RG was dramatically higher than that in the CG (P<0.05). Compared with the factors in the CG, the PF in the RG notably increased after treatment (P<0.05); the blood gas levels were noticeably better (P<0.05); and the level of inflammatory factors decreased (P<0.05). The incidence of complications in the RG was noticeably lower than that in the CG (P<0.05). The psychological status and QOL in the RG were remarkably better than those in the CG (P<0.05), and the recurrence rate within one year of diagnosis was lower than that in the CG (P<0.05).
CONCLUSION
Flu combined with CC is effective and safe in the treatment of COPD and can effectively improve the PF and the QOL of patients.
目的
探讨氟伐他汀（Flu）联合冬虫夏草胶囊（CC）对慢性阻塞性肺疾病（COPD）患者肺功能（PF）的影响。
方法
将我院收治的156例COPD患者进行分组：研究组（RG）86例，接受Flu加CC治疗；对照组（CG）70例，接受CC加常规药物治疗。比较两组治疗前后炎症因子，包括白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）和降钙素原（PCT）的变化。分析两组的并发症、心理状态、生活质量（QOL）及复发率。
结果
RG的总有效率显著高于CG（P<0.05）。与CG相比，RG治疗后PF显著升高（P<0.05）；血气水平明显改善（P<0.05）；炎症因子水平降低（P<0.05）。RG的并发症发生率显著低于CG（P<0.05）。RG的心理状态和QOL明显优于CG（P<0.05），诊断后一年内的复发率低于CG（P<0.05）。
结论
Flu联合CC治疗COPD有效且安全，可有效改善患者的PF和QOL。
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