布地奈德、沙丁胺醇及异丙托溴铵雾化吸入对喘息性肺炎患儿T淋巴细胞亚群及炎性细胞因子水平的影响
The effects of the atomization inhalation of budesonide, salbutamol, and ipratropium bromide on the T-lymphocyte subset and inflammatory cytokine levels in children with asthmatic pneumonia.
作者信息
Duan Yaqin, Zhou Huan, Chen Jianfeng
机构信息
Department of Pediatrics, The People's Hospital of Huangpi Wuhan 430300, Hubei Province, China.
出版信息
Am J Transl Res. 2021 Sep 15;13(9):10517-10526. eCollection 2021.
OBJECTIVE
This study aimed to explore the effects of the atomization inhalation of budesonide (BUD), salbutamol (SAL), and ipratropium bromide (IB) on the T-lymphocyte subset and inflammatory cytokine levels in children with asthmatic pneumonia (AP).
METHODS
A total of 118 children with AP admitted to our hospital were selected as the study cohort and randomly divided into two groups. The study group, included 67 patients who were treated with the atomization inhalation of BUD, SAL, and IB. The control group, included 51 patients who were treated with the atomization inhalation of BUD. The two groups were compared in terms of their symptom disappearance times, the therapeutic effects, inflammatory cytokine changes, their pulmonary function indices [C-reactive protein (CRP), respiratory frequency, forced vital capacity (FVC), one-second forced expiratory volume (FEV1), blood oxygen saturation (SpO2)], and their T-lymphocyte subset levels before and after the treatment, and the incidences of adverse reactions after the treatment.
RESULTS
The symptom disappearance times in the study group were shorter than they were in the control group (P<0.05), and the overall response rate (ORR) was significantly higher in the study group (P<0.05). The IL-5, IL-6, and IL-10 levels were all lower in the study group (P<0.05), but the interferon-γ levels were higher in this group (P<0.05). The CRP level was lower in the study group (P<0.05), but the FVC, FEV1, and SpO2 levels were higher in this group (P<0.05). After the treatment, the CD3, CD4 and CD4/CD8 levels were all higher in the study group (P<0.05), but the CD8 level was lower in this group (P<0.05). The incidence of adverse reactions in the study group was lower than it was in the control group (P=0.014).
CONCLUSION
The atomization inhalation of BUD, SAL, and IB is markedly effective in treating children with AP, and it can improve their immune function and reduce their inflammatory cytokines levels.
目的
本研究旨在探讨布地奈德（BUD）、沙丁胺醇（SAL）和异丙托溴铵（IB）雾化吸入对哮喘性肺炎（AP）患儿T淋巴细胞亚群及炎性细胞因子水平的影响。
方法
选取我院收治的118例AP患儿作为研究队列，随机分为两组。研究组67例，采用BUD、SAL和IB雾化吸入治疗；对照组51例，采用BUD雾化吸入治疗。比较两组症状消失时间、治疗效果、炎性细胞因子变化、肺功能指标[C反应蛋白（CRP）、呼吸频率、用力肺活量（FVC）、一秒用力呼气容积（FEV1）、血氧饱和度（SpO2）]、治疗前后T淋巴细胞亚群水平及治疗后不良反应发生率。
结果
研究组症状消失时间短于对照组（P<0.05），总有效率显著高于对照组（P<0.05）。研究组白细胞介素-5、白细胞介素-6和白细胞介素-10水平均较低（P<0.05），但干扰素-γ水平较高（P<0.05）。研究组CRP水平较低（P<0.05），但FVC、FEV１和SpO2水平较高（P<0.05）。治疗后，研究组CD3、CD4及CD4/CD8水平均较高（P<0.05），但CD8水平较低（P<0.05）。研究组不良反应发生率低于对照组（P=0.014）。
结论
BUD、SAL和IB雾化吸入治疗AP患儿疗效显著，可改善免疫功能，降低炎性细胞因子水平。
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