The effects of alprostadil combined with α-lipoic acid in the treatment of senile diabetic nephropathy.

OBJECTIVE

This study aimed to investigate the clinical efficacy of alprostadil combined with α-Lipoic acid (α-LA) in the treatment of senile diabetic nephropathy (SDN) and the combination's effect on the serum chemerin and neutrophil gelatinase-associated lipocalin (NGAL) expressions.

METHODS

Seventy-six patients with diabetic nephropathy (DN) admitted to our hospital from March 2018 to October 2019 were recruited as the research cohort. Among them, 36 patients who were administered alprostadil monotherapy were placed in the control group (CG), and the remaining 40 patients administered α-LA in addition to the alprostadil were placed in the research group (RG). The treatment effectiveness rate, the incidence of adverse reactions, and the changes in the renal function indexes (BUN, SCr, UAER) and the blood glucose indexes (FPG, 2hPG) were compared between the two groups.

RESULTS

The total effective rate in the RG was significantly higher than the total effective rate in the CG (P < 0.05). The renal function and blood glucose indexes dropped significantly after the treatment (P < 0.001). The chemerin and NGAL levels were significantly reduced in both groups after the treatment (P < 0.05), and the chemerin and NGAL expressions in the RG were significantly lower than they were in the CG (P < 0.05).

CONCLUSION

Alprostadil combined with α-LA is better than alprostadil monotherapy in the treatment of DN because it can improve the effectiveness rate, reduce the blood glucose, and improve the renal function while effectively reducing patients' serum chemerin and NGAL levels.