Shimada Shingo, Homma Tomoki, Koyanagi Kaname, Hamada Kazuya, Miura Chisako, Miura Ichiro, Abe Hironori
Department of Surgery, Hokkaido Social Work Association Obihiro Hospital, Obihiro, Hokkaido 080-0805, Japan.
Department of Pathology, Hokkaido Social Work Association Obihiro Hospital, Obihiro, Hokkaido 080-0805, Japan.
Mol Clin Oncol. 2021 Nov;15(5):233. doi: 10.3892/mco.2021.2396. Epub 2021 Sep 17.
Intracholecystic papillary neoplasm of the gallbladder (ICPN) is a type of intraductal papillary neoplasm of the bile duct that occurs in the gallbladder, and is a relatively newer concept. Therefore, there are few reports regarding ICPN. Menetrier's disease is a rare disease characterized by giant hypertrophy of the gastric folds that causes protein-losing gastroenteropathy (PLG). Although Menetrier's disease is a known risk factor for gastric adenocarcinoma, the association between Menetrier's disease and malignancy other than a malignancy of the stomach is unclear. A 69-year-old man presented to the Hokkaido Social Work Association Obihiro Hospital with gallbladder tumours diagnosed by ultrasonography at a previous institution. In addition, he had previously been diagnosed with PLG due to Menetrier's disease. Abdominal contrast-enhanced computed tomography (CT) revealed an irregular mass with a contrast effect at the fundus of the gallbladder on the free abdominal cavity side. Positron emission tomography-CT showed a tumour with a standard uptake value (SUV) of 8.28 at the fundus of the gallbladder. Cholecystectomy and resection of the gallbladder bed were performed. Based on the microscopy findings, the patient was diagnosed with ICPN. Although he had postoperative ileus, he was discharged 14 days postoperatively due to improvement through conservative treatment. Such cases of ICPN complicated with Menetrier's disease are extremely rare. However, patients with Menetrier's disease may need to be screened for malignancies.
胆囊内乳头状肿瘤（ICPN）是一种发生于胆囊的胆管内乳头状肿瘤，是一个相对较新的概念。因此，关于ICPN的报道较少。梅内特里耶病是一种罕见疾病，其特征为胃皱襞巨大肥厚，可导致蛋白丢失性胃肠病（PLG）。虽然梅内特里耶病是胃腺癌的已知危险因素，但梅内特里耶病与胃以外恶性肿瘤之间的关联尚不清楚。一名69岁男性因之前在其他机构经超声检查诊断为胆囊肿瘤，就诊于北海道社会福利协会带广医院。此外，他之前因梅内特里耶病被诊断为PLG。腹部增强计算机断层扫描（CT）显示在游离腹腔侧胆囊底部有一个有强化效应的不规则肿块。正电子发射断层扫描-CT显示胆囊底部有一个标准摄取值（SUV）为8.28的肿瘤。进行了胆囊切除术和胆囊床切除术。根据显微镜检查结果，该患者被诊断为ICPN。虽然他术后出现肠梗阻，但经保守治疗病情好转，术后14天出院。ICPN合并梅内特里耶病的病例极为罕见。然而，梅内特里耶病患者可能需要进行恶性肿瘤筛查。
