Aida Takashi, Tsunematsu Masashi, Furukawa Kenei, Haruki Koichiro, Shirai Yoshihiro, Onda Shinji, Toyama Yoichi, Gomisawa Kazutaka, Takahashi Hiroyuki, Ikegami Toru
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Surg Case Rep. 2021 Oct 24;7(1):229. doi: 10.1186/s40792-021-01312-6.
The intracystic papillary neoplasm (ICPN) is a newly established disease concept. It has been regarded as a preinvasive neoplastic lesion, similar to intraductal papillary mucinous neoplasm of the pancreas. Limited information is available on the clinical and imaging features of ICPN.
A 65-year-old woman was referred to our hospital for assessment of a gallbladder tumor. Contrast-enhanced computed tomography showed a papillary tumor in the fundus of the gallbladder with irregular thickening of the gallbladder wall that spread into the cystic duct. The boundary between the tumor and liver was unclear. The patient was diagnosed with gallbladder cancer with liver invasion. We performed extended cholecystectomy with liver bed resection after confirming the absence of cancer cells in the resection margin of the cystic duct. After pathological examination, the tumor was diagnosed as an ICPN with xanthogranulomatous cholecystitis. The patient was discharged on postoperative day 8 with no complications.
We have described a rare case of ICPN concomitant with xanthogranulomatous cholecystitis. Clinicians should include ICPN as a differential diagnosis in patients with a papillary or polypoid tumor in the gallbladder.
囊内乳头状肿瘤（ICPN）是一个新确立的疾病概念。它被视为一种浸润前肿瘤性病变，类似于胰腺导管内乳头状黏液性肿瘤。关于ICPN的临床和影像学特征的信息有限。
一名65岁女性因胆囊肿瘤评估被转诊至我院。增强计算机断层扫描显示胆囊底部有一个乳头状肿瘤，胆囊壁不规则增厚并蔓延至胆囊管。肿瘤与肝脏之间的边界不清。患者被诊断为胆囊癌伴肝侵犯。在确认胆囊管切缘无癌细胞后，我们进行了扩大胆囊切除术并切除肝床。病理检查后，肿瘤被诊断为伴有黄色肉芽肿性胆囊炎的ICPN。患者术后第8天出院，无并发症。
我们描述了一例罕见的ICPN合并黄色肉芽肿性胆囊炎的病例。临床医生应将ICPN纳入胆囊乳头状或息肉样肿瘤患者的鉴别诊断中。
