Hidar Samir, Alimi Amal, Khlifi Abdejlil, Chachia Selma, Kaabia Ons, Bouguizane Sassi, Bibi Mohamed, Khairi Hédi
Department of Obstetrics and Gynaecology, F. Hached University Teaching Hospital, Sousse, Tunisia.
Eur J Breast Health. 2021 Oct 4;17(4):352-355. doi: 10.4274/ejbh.galenos.2021.2021-4-11. eCollection 2021 Oct.
Radio isotopes and blue dyes alone or in combination are the most commonly used tracer agents in sentinel node (SN) biopsy for early breast cancer. Recent studies have found fluorescence method using indocyanine green (ICG) as a promising technology with fewer disadvantages.
Retrospective analysis of our database that included patients with clinically node-negative breast cancer scheduled for breast surgery and SN biopsy between 2016 and January 2021. Patients who underwent detection using fluorescence-ICG were included in this study.
A total of 47 patients were included. Median age was 50 (range: 24-78) years. Mean tumor size was 3.4 ± 1.5 cm. All patients received ICG injection and 11 received a combination of ICG and blue dye. Forty-five successful SN identifications with ICG were performed and 99 nodes retrieved. Eleven procedures were undertaken after initial systemic therapy. Twenty-four patients had at least one positive SN for malignancy. Mean follow up was 29.2 months and no axillary recurrence was noted during the study period.
ICG appears to be a feasible and accurate method for SN biopsy with high identification rate. This is the first study of ICG in sentinel node biopsy in a North African population.
放射性同位素和蓝色染料单独或联合使用是早期乳腺癌前哨淋巴结（SN）活检中最常用的示踪剂。最近的研究发现，使用吲哚菁绿（ICG）的荧光方法是一种很有前景的技术，缺点较少。
回顾性分析我们的数据库，该数据库纳入了2016年至2021年1月期间计划接受乳房手术和SN活检的临床淋巴结阴性乳腺癌患者。本研究纳入了接受荧光ICG检测的患者。
共纳入47例患者。中位年龄为50岁（范围：24 - 78岁）。平均肿瘤大小为3.4±1.5厘米。所有患者均接受了ICG注射，11例接受了ICG与蓝色染料联合使用。使用ICG成功识别出45个SN，共取出99个淋巴结。11例手术在初始全身治疗后进行。24例患者至少有一个SN为恶性阳性。平均随访29.2个月，研究期间未发现腋窝复发。
ICG似乎是一种可行且准确的SN活检方法，识别率高。这是在北非人群中关于ICG在前哨淋巴结活检中的第一项研究。
