Pierson M, Leheup B, Schweitzer C, Mangin E
Acta Endocrinol Suppl (Copenh). 1986;279:130-4. doi: 10.1530/acta.0.112s130.
Twenty five of the 75 patients having been given human growth hormone in the Pediatric Nancy Endocrinological Division have reach final adult height. All have been treated the same way, 10 boys and 4 girls were diagnosed as isolated deficit, 7 boys and 4 girls as combined deficit. The physical, sexual, radiological, intellectual, professional and psychological characteristics have been defined either during the treatment follow-up or at a final interview. All results have been compared to the familial conditions if possible. Final adult statures are in the low range of the normal (-2 DS). The sexual development, normal for patients with isolated deficit, has not been achieved completely by regular protocol for patients with combined deficit. The intellectual and professional achievements are rather low but this has to be matched with below the normal familial conditions. Psychological determination is quite satisfactory but the personality is dominated by shyness and lack of responsibility. It is likely that an earlier onset of treatment and a better psychological guidance may lead to a better final results judged both on physical grounds but also on psychological and professional conditions.
在南锡儿科内分泌科接受人生长激素治疗的75名患者中，有25名已达到最终成人身高。所有患者的治疗方式相同，10名男孩和4名女孩被诊断为单纯性生长激素缺乏，7名男孩和4名女孩为复合型生长激素缺乏。在治疗随访期间或末次访谈时确定了身体、性征、影像学、智力、职业和心理特征。如果可能的话，所有结果都与家庭情况进行了比较。最终成人身高处于正常范围的低限（低于正常均值2个标准差）。单纯性生长激素缺乏患者的性发育正常，而复合型生长激素缺乏患者未按常规方案完全实现性发育。智力和职业成就相当低，但这必须与低于正常的家庭情况相匹配。心理测定结果相当令人满意，但个性以害羞和缺乏责任感为主。很可能更早开始治疗并给予更好的心理指导，从身体、心理和职业状况等方面判断，可能会带来更好的最终结果。
