Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
J Magn Reson Imaging. 2022 May;55(5):1504-1515. doi: 10.1002/jmri.27939. Epub 2021 Oct 15.
Magnetic resonance imaging (MRI) is increasingly being used in the diagnosis and treatment planning of uveal melanoma (UM), the most common primary intraocular tumor. Initially, 7 T MRI was primarily used, but more recently these techniques have been translated to 3 T, as it is more commonly available.
Compare the diagnostic performance of 3 T and 7 T MRI of UM.
Prospective.
Twenty-seven UM patients (19% female).
FIELD STRENGTH/SEQUENCE: 3 T: T1- and T2-weighted three-dimensional (3D) spin echo (SE) and multi-slice (MS) SE, 7 T: T1-weighted 3D gradient echo (GE), T2-weighted 3D SE and MS SE, 3 T and 7 T GE dynamic contrast-enhanced. T1 weighted images: acquired before and after Gadolinium (Gd) administration.
For all sequences, scan and diagnostic quality was quantified using a 5-point Likert scale. Signal intensities on T1 and T2 relative to choroid and eye muscle respectively were assessed as well as the tumor prominence. Finally, the perfusion time-intensity curves (TICs) were classified as plateau, progressive, or wash-out.
Image quality scores were compared between both field strengths using Wilcoxon signed-rank and McNemar tests. Paired t-tests and Bland-Altman were used for comparing tumor prominences. P < 0.05 was considered statistically significant.
Image quality was comparable between 3 T and 7 T, for 3DT1, 3DT2, 3DT1Gd (P = 0.86; P = 0.34; P = 0.78, respectively) and measuring tumor dimensions (P = 0.40). 2DT1 and 2DT2 image quality were rated better on 3 T compared to 7 T. Most UM had the same relative signal intensities at 3 T and 7 T on T1 (17/21) and T2 (13/17), and 16/18 diagnostic TICs received the same classification. Tumor prominence measurements were similar between field strengths (95% confidence interval: -0.37 mm to 0.03 mm, P = 0.097).
Diagnostic performance of the evaluated 3 T protocol proved to be as capable as 7 T, with the addition of 3 T being superior in assessing tumor growth into nearby anatomical structures compared to 7 T.
2 TECHNICAL EFFICACY: Stage 3.
磁共振成像（MRI）在葡萄膜黑色素瘤（UM）的诊断和治疗计划中越来越多地被使用，UM 是最常见的原发性眼内肿瘤。最初主要使用 7T MRI，但最近这些技术已被转化为 3T，因为它更常用。
比较 UM 的 3T 和 7T MRI 的诊断性能。
前瞻性。
27 名 UM 患者（19%为女性）。
场强/序列：3T：T1 和 T2 加权三维（3D）自旋回波（SE）和多切片（MS）SE，7T：T1 加权 3D 梯度回波（GE），T2 加权 3D SE 和 MS SE，3T 和 7T GE 动态对比增强。T1 加权图像：在钆（Gd）给药前后采集。
对于所有序列，使用 5 分李克特量表量化扫描和诊断质量。还评估了 T1 和 T2 相对于脉络膜和眼外肌的信号强度以及肿瘤突出度。最后，将灌注时间-强度曲线（TICs）分类为平台型、渐进型或洗脱型。
使用 Wilcoxon 符号秩和检验和 McNemar 检验比较两种场强之间的图像质量评分。使用配对 t 检验和 Bland-Altman 检验比较肿瘤突出度。P<0.05 被认为具有统计学意义。
3T 和 7T 之间的图像质量相当，3DT1、3DT2、3DT1Gd（P=0.86；P=0.34；P=0.78）和测量肿瘤尺寸（P=0.40）的图像质量。与 7T 相比，2DT1 和 2DT2 的图像质量在 3T 上的评分更高。大多数 UM 在 T1（17/21）和 T2（13/17）上的相对信号强度在 3T 和 7T 上相同，并且 16/18 个诊断 TIC 获得了相同的分类。肿瘤突出度测量在两种场强之间相似（95%置信区间：-0.37mm 至 0.03mm，P=0.097）。
评估的 3T 方案的诊断性能与 7T 一样出色，并且 3T 在评估肿瘤向附近解剖结构生长方面优于 7T。
2 技术功效：第 3 阶段。
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