Laffon de Mazières Clarisse, Lapeyre-Mestre Maryse, Vellas Bruno, de Souto Barreto Philipe, Rolland Yves
Department of Geriatric Medicine, Toulouse University Hospital (CHU de Toulouse), Gérontopôle, Toulouse, France.
Inserm UMR 1027, 37 Allées Jules Guesde, Toulouse, France.
Eur Geriatr Med. 2019 Apr;10(2):285-293. doi: 10.1007/s41999-018-00155-z. Epub 2019 Feb 6.
To study the effect of a quality assurance approach in a nursing home, with or without the intervention of a geriatrician, on the potentially inappropriate prescription of antipsychotics (PIPA) at 18 months; and to identify the factors associated with PIPA after 18 months of intervention (T18).
We used data from a multicentre individually tailored controlled trial (IQUARE study). The study population comprised residents included in the IQUARE study with at least one potentially inappropriate prescription of antipsychotics at baseline (T0) who were still in nursing home at T18 (n = 636; nursing homes = 175). The control group received individual feedback from the quality assurance audit performed at baseline. The intervention group also had at least 5 collaborative work meetings with a geriatrician over an 18-month period. We used a multilevel logistic regression model.
The rates of inappropriate antipsychotic drug prescribing were 66.5% and 45.2% at T0 and T18, respectively. This decrease in the rate of PIPA is significant (p < 0.001). A significant decrease was found within each group: in the intervention arm (68.1% at T0 vs. 44.6% at T18; p < 0.001) and in the control arm (65.2% at T0 vs. 45.6% at T18; p < 0.001). Multivariate analysis did not highlight any statistically significant association between living in a nursing home having received an intervention and PIPA at T18.
Collaborative work meetings with a geriatrician does not provide significant added value to a global quality assurance approach towards PIPA. Individual feedback to each nursing home appears to have a substantial impact on decreasing PIPA.
研究在养老院中采用质量保证方法,无论有无老年病医生的干预,在18个月时对抗精神病药物潜在不适当处方(PIPA)的影响;并确定干预18个月(T18)后与PIPA相关的因素。
我们使用了一项多中心个体化定制对照试验(IQUARE研究)的数据。研究人群包括IQUARE研究中在基线(T0)时至少有一项抗精神病药物潜在不适当处方且在T18时仍住在养老院的居民(n = 636;养老院 = 175)。对照组接受了基线时质量保证审核的个人反馈。干预组在18个月内还与一名老年病医生至少举行了5次协作工作会议。我们使用了多水平逻辑回归模型。
T0和T18时抗精神病药物不适当处方率分别为66.5%和45.2%。PIPA率的这种下降具有显著性(p < 0.001)。每组内均发现显著下降:干预组(T0时为68.1%,T18时为44.6%;p < 0.001)和对照组(T0时为65.2%,T18时为45.6%;p < 0.001)。多变量分析未突出显示接受干预的养老院与T18时的PIPA之间存在任何统计学上的显著关联。
与老年病医生的协作工作会议并未为针对PIPA的全面质量保证方法提供显著的附加价值。向每个养老院提供的个人反馈似乎对降低PIPA有重大影响。